免疫调控与慢性炎症性疾病课题组

发布时间:2017-03-06         浏览次数:131

免疫调控与慢性炎症性疾病课题组

课题组长简介

 

    胡德胜,男,博士,厦门大学公共卫生学院教授。山东中医药大学医学硕士(2007);德国莱布尼兹老年病研究所/耶拿大学博士(2012);2012-2013年德国莱布尼兹老年病研究所博士后;2013-2016年德国赫姆霍兹分子免疫学研究所,德国慕尼黑大学免疫学研究所博士后;201612月加入厦门大学公共卫生学院,获聘为教授,免疫学课题组组长。

 

研究领域

2007年起致力于血管免疫学方面的研究,研究发现老年动脉粥样硬化模型小鼠动脉外膜形成类似淋巴结内部结构的免疫组织,称之为动脉三级淋巴组织(J Exp Med,2009)。研究表明,此三级淋巴组织对内膜动脉粥样硬化斑块的形成有一定的调控作用,但具体的机理尚不明确,研究成果发表在免疫学顶级期刊Immunity (2015)。另外,还对RNA结合蛋白RoquinTh17Treg细胞的形成及炎症反应过程中的作用做了深入的研究,相关研究结果发表在免疫学另一顶级期刊上Nature Immunity(2015).

课题组将继续致力于免疫调控与慢性炎症性疾病方面的研究。

 

发表文章

1.Hu D*., Mohanta S*.,et alHabenicht A.,.Artery Tertiary Lymphoid Organs Control Aorta

Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxinb Receptors.Immunity42, 1100-1115(2015). (2015IF:24.08

2.Jeltsch K.*,Hu D.*,et al., Heissmeyer V., Cleavage of roquin and regnase-1 by the paracaspase

MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.

Nat Immunology 15, 1079-1089 (2014) * equal contribution.(2015IF:19.38

3.Hu D.,Yin C.,et al, Preparation of Single Cell Suspensions from Mouse Aorta.Bio-Protocol,2016 June 5;6(11).pii: e1882. (first and corresponding author)

4.Srikakulapu P.*,Hu D.*, et al,Habenicht A.,.Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.Arterioscler Thromb Vasc Biol.2016(36):1174-1185.* equal contribution. (IF: 6.0)

5.Meininger I,Griesbach RA,Hu D.,et al., Krappmann D.,Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.Nat Commun.2016(7), pii:e11292(IF:11.33)

6.Mohanta S., Yin C., Weber C.,Hu D.,Habenicht A.,Aorta Atherosclerosis Lesion Analysis in Hyperlipidemic Mice.Bio-Protocol,2016 June 5;6(11).pii: e1883.

7.Srivastava M., Duan G.,Hu D., Vinuesa C.,et al. Roquin binds microRNA-146a and Argonaute 2 and regulate microRNA homeostasis.Nat Commun. 2015(6):6253.

8.Yin, C.,Mohanta, S.,Hu, D., Weih, F., and Habenicht, A..Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays. Methods Mol Biol,2015. (1339):297-308.

9.Mohanta S, Yin C, Peng L, Srikakulapu P,Hu D, et al. Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis.Circulation Res.2014. 114(11):1772-87

10.Krljanac B., Weih D., Jacobsen ID.,Hu D.,et al. NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.Eur J Immunol. 2014. 44(3):662-72.

11.Weih F, Gräbner R,Hu D., Beer M, Habenicht AJR.Control of Dichotomic Innate and Adaptive Immune Responses by Artery Tertiary Lymphoid Organs in Atherosclerosis.Front Physiol.2012(3):226-231.

12.Beer M, Doepping S, Hildner M, Weber G, Gräbner R,Hu D., Mohanta SK, Srikakulapu P, Weih F, Habenicht AJR. Laser-capture microdissection of hyperlipidemic/ApoE-/- mouse aorta atherosclerosis.Methods in Molecular Biology, 2011 (755):417-428.

13.Gräbner R, Lötzer K, Döpping S, Hildner M,Hu D., Randolph GJ, Weih F, Habenicht AJ.Lymphotoxinβ Receptor Signaling Promotes Tertiary Lymphoid Organogenesis in the Aorta Adventitia of Aged ApoE-/- Mice.J. Exp. Med, 2009 (206): 233-248.

奖励与资助:

2015年德国赫姆霍兹优秀科研奖

2016年德国跨学科合作交流奖

2016年德国弗里德里希鲍尔国际科研基金

 

联系方式

通信地址:厦门市翔安区翔安南路厦门大学公共卫生学院曾宪梓楼411

邮编:361102

电子邮箱:desheng.hu@xmu.edu.cn