程通

发布时间:2015-07-21         浏览次数:2108


程通,CHENG TongPh.D.

副教授,Associate Professor            

话:+86-592-2184113

E-mailtcheng@xmu.edu.cn

1999年,厦门大学生物学专业,学士学位

2006年,厦门大学动物学专业,博士学位                 


研究领域(Research Area

主要从事病毒分子生物学、反向疫苗学、人源化动物模型的研究工作,目前研究方向包括肠道病毒广谱中和表位与疫苗研究,水痘-带状疱疹病毒反向疫苗学与减毒作用机制研究,乙型肝炎病毒人源化动物模型研究。

近年发表论文(*通讯作者):

[1]Xu L,He D, Li Z, Yang L, Zheng J, Yu H, Zhao H, Ye X, Qian H, Wang W, Liu J, Que Y, ShihJW, Zhang J, Zhu H, Cheng T*,Xia N*. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopeswithin the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Scientific Reports. 2015  [Epub ahead of print]

[2]LiuJ, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, ZhuH, Cheng T*, Xia N. Amonoclonal antibody-based VZV Glycoprotein E Quantitative Assay and ItsApplication on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol,2015, 99(11):4845-4853

[3]HouW, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T*, Xia N*. Constructionand characterization of an infectious cDNA clone of Echovirus 25.Virus Res. 2015, 205:41-44

[4]HouW, Yang L, He D, Zheng J, Xu L, Liu J, Liu Y, Zhao H, Ye X, Cheng T*, Xia N. Development ofa coxsackievirus A16 neutralization test based on the enzyme-linked immunospotassay. J Virol Methods. 2015, 215-216:56-60

[5]Xu L, He D, Li Z, Zheng J, Yang L, Yu M, YuH, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, ChengT*, Xia N. Protection againstlethal Enterovirus 71 challenge in mice by a recombinant vaccine candidatecontaining a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics.2014, 4(5):498-513. (cover paper)

[6]Yang L, He D, Tang M, Li Z, Liu C, Xu L,Chen Y, Du H, Zhao Q, Zhang J, Cheng T*, Xia N.Development of an enzyme-linked immunosorbent spot assay to measureserum-neutralizing antibodies against coxsackievirus B3. Clin Vaccine Immunol. 2014,21(3):312-20.

[7]Li Z, Xu L, He D, Yang L, Liu C, Chen Y,Shih JW, Zhang J, Zhao Q, Cheng T*,Xia N*. In Vivo Time-Related Evaluation of a Therapeutic NeutralizationMonoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model. PLoS One. 2014, 9(10):e109391.

[8]ChenL, Liu J, Wang W, Ye J, Wen L, Zhao Q, Zhu H,Cheng T*, Xia N. Development ofa Varicella-zoster virus neutralization assay using a glycoprotein K antibodyenzyme-linked immunosorbent spot assay. J Virol Methods, 2014, 200C:10-14.

[9]Mao Q1, Cheng T1, Zhu F1, Li J, WangY, Li Y, Gao F, Yang L, Yao X, Shao J, Xia N, Liang Z, Wang J. Thecross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines inhealthy chinese infants and children. PLoS One. 2013, 8(11):e79599. co-1st

[10]Wang W, Cheng T*, Ma K, Xia D,Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N. Development of a novelbaculovirus titration method using the Enzyme-linked immunosorbent spot(ELISPOT) assay. JVirol Methods. 2013, 188(1-2):114-20.

[11]Zhang T1,Cheng T1, Wei L,Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1replication by an artificial polycistronic miRNA construct. Virol J. 2012, 9(1):118. co-1st

[12]Zhang YL, ChengT*, Cai YJ, Yuan Q, LiuC, Zhang T, Xia DZ, Li RY, Yang LW, Wang YB, Yeo AE, Shih JW, Zhang J, Xia NS.RNA Interference inhibits hepatitis B virus of different genotypes in vitro andin vivo. BMC Microbiol. 2010, 10:214.

[13]ChengT, Xu CY, Wang YB, ChenM, Wu T, Zhang J, Xia NS. A rapid and efficient method to express target genesin mammalian cells by baculovirus. World J Gastroenterol. 2004,10:1612-1618

[14]Spiess K, Jeppesen MG, Malmgaard-Clausen M,Krzywkowski K, Dulal K, Cheng T,Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN,Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral Gprotein-coupled receptor US28 potently inhibits cytomegalovirus infection invivo. Proc Natl Acad Sci USA. 2015 Jun 15. pii: 201509392.

[15]Selariu A, Cheng T, Tang Q, Silver B, YangL, Liu C, Ye X, Markus A, Goldstein RS, Cruz Cosme RS, Lin Y, Wen L, Qian H,Han J, Dulal K, Huang Y, Li Y, Xia N, Zhu H. ORF7 of Varicella Zoster Virus isa Neurotropic Factor.JVirol. 2012 , 86(16):8614-24.

[16]Zhang Z, Selariu A, Warden C, Huang G, Huang Y,Zaccheus O, Cheng T, Xia N,Zhu H. Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropicfactor. PLoS Pathog. 2010, 6(7):e1000971.