何承勇

发布时间:2013-05-15         浏览次数:2325

何承勇副教授(硕士生导师)

理学博士(厦门大学,生命科学学院)

学术简历:

2003/09-2007/06,南京农业大学,无锡渔业学院,本科

2007/09–2009/09,厦门大学,生命科学学院,硕士研究生

2011/09–2012/08Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, USA国家留学基金委公派联合培养博士

2009/09–2012/12,厦门大学,生命科学学院生物学系动物学,博士

2013/01–2018/02,厦门大学,公共卫生学院预防医学系,助理教授

2018/02–至今,厦门大学,公共卫生学院预防医学系,副教授

讲授课程:

本科生课程:《毒理学基础》、《毒理学实验技术与方法》、《公共卫生人文案例》、《环境生理学》、《环境因素与健康》等

研究生课:《现代实验预防医学》、《毒理学教程》、《高级职业病学》等

研究方向:

学科专业:环境毒理学;纳米毒理学

科研方向:环境污染物毒性作用及机制研究;纳米生物安全性评价

主要开展的研究内容:

(1) PAHs对神经发育、行为记忆影响及分子机制研究;

(2)重金属镉肝肾毒性及分子机制;

(3)内质网应激、线粒体质量控制评价纳米材料生物安全性

主持和参与科研课题:

1.厦门大学校长基金,20720180045,未折叠蛋白反应ATF4通路调控内质网自噬介导量子点肾损伤机制研究与应用2018/1-2020/12,在研,主持

2.国家自然科学基金青年项目,81402648,多环芳烃通过NO介导的亚硝基化影响海马神经发育的机制研究,2015/01-2017/12,已结题,主持

3.福建省中青年教师教育科研项目(A)(福建省教育厅科技项目)JA14004,苯并芘经NO介导蛋白亚硝基化影响海马神经发育的机制,2015/1-2017/5,已结题,主持

4.国家自然科学基金面上项目,81773465,环氧合酶2蛋白质稳态调控线粒体偶联的内质网功能介导肝毒性的机制研究,2018/01-2021/12,在研,参加

5.国家自然科学基金面上项目,81673129,耐铬菌株中还原酶介导环境铬(VI)降解及其诱导小鼠肝细胞功能的机制研究,2017/01-2020/12,在研,参加

6.国家自然科学基金面上项目,21577113,多氯联苯诱导糖尿病发生发展的过程及机理研究,2016/01-2019/12,参加

7.国家自然科学基金面上项目,81573181PP2A介导抑癌蛋白转录非依赖性通路对外源物诱导线粒体质量控制的调控,2016/01-2019/12,在研,参加

8.福建省自然科学基金项目,2015J01344AFB1诱导肝细胞坏死性凋亡的线粒体自噬信号通路调控机制研究,2015/04-2018/04,在研,参加

9.国家自然科学基金面上项目,81472997,靶向蛋白磷酸酶2A信号调控是AFB1HBx协同诱导肝毒性的一条新通路,2015/01-2018/12在研,参与

10. 973计划前期研究专项,2014CB560710,微生物致癌因子诱导细胞恶性转化的分子机制研究,2014/10-2016/10,已结题,参与

11.国家自然科学基金面上项目,20977071,不同环数的多环芳烃对海洋鱼类早期骨骼发育的影响及其分子机制,2010/01-2012/12,已结题,参与

12.国家科技支撑计划,2007BAC27B02POPs的机体负荷与健康效应评价技术研发,2008.1-2012.12,已结题,参与

主持教学改革项目:

1.第三学期本科生系列学术沙龙的探索与实践

发表的SCI论文:

1. Shengwei Jiang#, Yuchun Lin#, Huan Yao#, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu*, Zhongning Lin*, Chengyong He*. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study.Archives of Toxicology.2018;92(541) 1-14.(IF=5.901, JCR1,共通讯)

2.Chengyong He#, Shengwei Jiang#, Haijing Jin#, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin*, Zhongning Lin*,Gang Liu*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity.Biomaterials. 2016;83:102-114.(IF=8.557, JCR1,共一)

3. Bing Luo#, Yuchun Lin#, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu,Chengyong He*, Zhongning Lin*.Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-inducedautophagy in kidney.Cell Death & Disease.2016;7: e2251; doi:10.1038/cddis.2016.78 (IF=5.965, JCR2,共通讯)

4.Mei Chen#, Shuzhen Chen#,Chengyong He#, Shiguang Mo, Xiaoyong Wang, Gang Liu*, and Nanfeng Zheng*, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging.Nano Research.2017;10(4): 1234–1248(IF=7.354, JCR1,共一)

5. Duc-Viet Nguyen, Shengwei Jiang,Chengyong He, Zhongning Lin*, Naibo Lin, Anh-Tuan Nguyen, Lifeng Kang, Ming-Yong Han, and Xiang-Yang Liu* Elevating Biomedical Performance of ZnO/SiO2@Amorphous Calcium Phosphate-Bioinspiration Making Possible the Impossible.Advanced Functional Materials.2016;26: 6921–6929.(IF=12.124, JCR1)

6.Teng-Jian Zhou, Shi-Li Zhang,Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Sheng-Wei Jiang, Huan Yao, Yi-Jun Huang, Wen-Hua Ling, Yu-Chun Lin *,Zhong-Ning Lin*. Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin related-protein 1.Theranostics. 2017;7(5):1389-06.(IF=8.712, JCR1)

7. Qunying Zhuang#, Tengjian Zhou#,Chengyong He, Shili Zhang, Yang Qiu, Bing Luo, Ran Zhao, Hengchuan Liu, Yuchun Lin*and Zhongning Lin*.Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b.Journal of Experimental & Clinical Cancer Research.2016;35:67 DOI 10.1186/s13046-016-0341-z.(IF=5.189, JCR2)

8. Shuzhen Chen#, Jun Zhang#, Shengwei Jiang, Gan Lin, Bing Luo, Huan Yao, Yuchun Lin,Chengyong He, Gang Liu* and Zhongning Lin* Self-Assembled Superparamagnetic Iron Oxide Nanoclusters for Universal Cell Labeling and MRI.Nanoscale Research Letter.2016 Dec;11(1):263.3.(IF= 2.833, JCR 2)

9. Kun Liao, Bin Xia, Qun-Ying Zhuang, Meng-Jun Hou, Yu-Jing Zhang, Bing Luo, Yang Qiu, Yan-Fang Gao, Xiao-Jie Li, Hui-Feng Chen, Wen-Hua Ling,Cheng-Yong He,Yi-Jun Huang, Yu-Chun Lin*, Zhong-Ning Lin*. Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway.Theranostics.2015; 5(3):302-321. (IF=8.712, JCR1)

10.Chengyong He,Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo*. Tissue-specific and embryonic expression of the retinoid X receptors inSebastiscus marmoratus.Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology.2009; 154(2):221-228. (IF=1.923, JCR4)

11.Chengyong He,Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang*. Effects of Benzo(a)Pyrene on the skeletal development ofSebastiscus marmoratusembryos and the molecular mechanism involved.Aquatic Toxicology.2011;101:335–341. (IF=3.761, JCR2)

12.Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo*. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus).Neurotoxicology.2012; 33:758-762. (IF=3.096, JCR3)

13.Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo*. Exposure ofSebastiscus marmoratusembryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms.Aquatic Toxicology.2012;116-117: 109-115. (IF=3.761, JCR2)

14.Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang*, Pyrene exposure influences the thyroid development ofSebastiscus marmoratusembryos.Aquatic Toxicology.2012:124-125C;28-33. (IF=3.761, JCR2)

15. Xiao Shi,Chengyong He, Zhenghong Zuo, Ruixia Li, Chen, Donglei Chen, Rong Wang, Chonggang Wang*, Pyrene exposure influences the craniofacial cartilage development ofSebastiscus marmoratusembryos.Marine Environmental Research.2012;77:30-34. (IF=2.276, JCR3)

16. Jiliang Zhang, Zhenghong Zuo,Chengyong He, Di Wu, Yixin Chen and Chonggang Wang*. Inhibition of thyroidal status related to depression of testicular development inSebastiscus marmoratusexposed to tributyltin.Aquatic Toxicology.2009:94(1): 62-67.(IF=3.761, JCR2)

17. Jiliang Zhang, Zhenghong Zuo,Chengyong He, Jiali Cai, Yuqing Wang, Yixin Chen and Chonggang Wang*. Effect of tributyltin on testicular development inSebastiscus marmoratusand the mechanism involved.Environmental Toxicology and Chemistry.2009 Jul;28(7):1528-35. (IF=2.809, JCR3)

18. Ruixia Li, Zhenghong Zuo, Denglei Chen,Chengyong He, Rong Chen, Yixin Chen, Chonggang Wang*. 2011. Inhibition by polycyclic aromatic hydrocarbons of ATPase activities inSebastiscus marmoratuslarvae: relationship with the development of early life stages.Marine Environmental Research.2011;71(1): 86-90. (IF=2.276, JCR3)

联系方式:

地址:福建省厦门市翔安区翔安南路,厦门大学公共卫生学院(邮编361102)

电话:0592-2880638

传真:0592-2181578

Emailhecy@xmu.edu.cn