何承勇

发布时间:2013-05-15         浏览次数:2095

 何承勇

 助理教授(硕士生导师)

 理学博士 (厦门大学,生命科学学院动物学)

 


学术简历:

2003/09-2007/06,南京农业大学,无锡渔业学院,本科

2007/09–2009/09,厦门大学,生命科学学院,硕士研究生

2011/09–2012/08Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, USA国家留学基金委公派联合培养博士

2009/09–2012/12,厦门大学,生命科学学院生物学系动物学,博士

2013/01–至今,厦门大学,公共卫生学院预防医学系,助理教授 

讲授课程:

   本科生课程毒理学基础》、《毒理学实验技术与方法》、《公共卫生人文案例》、《环境生理学》、《环境因素与健康》等。

 研究生课现代实验预防医学》。

研究方向:

 学科专业:环境毒理学;纳米毒理学

 科研方向:环境污染物毒性作用及机制研究;纳米生物安全性评价

 主要开展的研究内容:

(1) PAHs对神经发育、行为记忆影响及分子机制研究;

(2)重金属镉肝肾毒性及分子机制;

(3)内质网应激、线粒体质量控制评价纳米材料生物安全性。

主持和参与的课题:

1. 国家自然科学基金青年项目,81402648,多环芳烃通过NO介导的亚硝基化影响海马神经发育的机制研究,2015/01-2017/12,在研,主持

2. 福建省中青年教师教育科研项目(A)(福建省教育厅科技项目)JA14004,苯并芘经NO介导蛋白亚硝基化影响海马神经发育的机制,2015/1-2017/12,主持

3. 国家自然科学基金面上项目,81573181PP2A介导抑癌蛋白转录非依赖性通路对外源物诱导线粒体质量控制的调控,2016/01-2019/12,在研,参加

4. 国家自然科学基金面上项目,21577113,多氯联苯诱导糖尿病发生发展的过程及机理研究,2016/01-2019/12,在研,参加

5. 福建省自然科学基金项目,2015J01344AFB1诱导肝细胞坏死性凋亡的线粒体自噬信号通路调控机制研究,2015/04-2018/04,在研,参加

6. 国家自然科学基金面上项目,81472997,靶向蛋白磷酸酶2A信号调控是AFB1HBx协同诱导肝毒性的一条新通路,2015/01-2018/12,在研,参与

7.  973计划前期研究专项,2014CB560710,微生物致癌因子诱导细胞恶性转化的分子机制研究,2014/10-2016/10,在研,参与

8. 福建省自然科学基金项目,2014J01372PP2A亚基基因多态性调控HBx蛋白靶向及其介导肝细胞毒性转归的功能研究,2014/01-2016/12,在研,参与

9. 厦门大学山海基金项目,2013SH007PP2A亚基基因多态性调控HBx蛋白靶向及其介导肝细胞毒性转归的功能研究,2013/01-2016/12,在研,参与

10. 国家自然科学基金面上项目,20977071,不同环数的多环芳烃对海洋鱼类早期骨骼发育的影响及其分子机制,2010/01-2012/12,已结题,参与

11. 国家科技支撑计划,2007BAC27B02POPs的机体负荷与健康效应评价技术研发,2008.1-2012.12,已结题,参与 

发表的SCI论文

1. Chengyong He#, Shengwei Jiang#, Haijing Jin#, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji; Yuchun Lin*; Zhongning Lin*; Gang Liu*, Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity,Biomaterials, 83, pp 102-114, 2016/1/6.(IF=8.557, JCR1)

2.  Bing Luo#, Yuchun Lin#, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu,Chengyong He*, Zhongning Lin*.Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney.Cell death & Disease (Accepted). (IF=5.04, JCR2)

3.  Kun Liao, Bin Xia, Qun-Ying Zhuang, Meng-Jun Hou, Yu-Jing Zhang, Bing Luo, Yang Qiu, Yan-Fang Gao, Xiao-Jie Li, Hui-Feng Chen, Wen-Hua Ling,Cheng-Yong He, Yi-Jun Huang, Yu-Chun Lin*, Zhong-Ning Lin*.Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway.Theranostics 2015; 5(3):302-321. (IF=8.03, JCR2)

4. Chengyong He,Chonggang Wang, Bowen Li, FazhiXie, Yixin Chen, Zhenghong Zuo*. Tissue-specific and embryonic expression of the retinoid X receptors inSebastiscusmarmoratus.Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (2009) 154(2):221-228. (IF=1.923, JCR4)

5. Chengyong He,Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang*. Effects of Benzo(a)Pyrene on the skeletal development ofSebastiscusmarmoratusembryos and the molecular mechanism involved.Aquatic Toxicology (2011) 101 335–341. (IF=3.761, JCR2)

6. Chengyong He,Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo*. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscusmarmoratus).Neurotoxicology (2012) 33, 758-762. (IF=3.096, JCR3)

7. Chengyong He,Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo*. Exposure ofSebastiscusmarmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms.Aquatic Toxicology(2012)116-117, 109-115. (IF=3.761, JCR2)

8. Chengyong He,Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang*, Pyrene exposure influences the thyroid development ofSebastiscusmarmoratus embryos.Aquatic Toxicology (2012)124-125C, 28-33. (IF=3.761, JCR2)

9.  Xiao Shi,Chengyong He,Zhenghong Zuo, Ruixia Li, Chen, Donglei Chen, Rong Wang, Chonggang Wang*, Pyrene exposure influences the craniofacial cartilage development of Sebastiscus marmoratus embryos.Marine Environmental Research(2012) 77, 30-34. (IF=2.276, JCR3)

10.  Jiliang Zhang, Zhenghong Zuo,Chengyong He, Di Wu, Yixin Chen and Chonggang Wang*. Inhibition of thyroidal status related to depression of testicular development inSebastiscus marmoratus exposed to tributyltin.Aquatic Toxicology(2009)94(1): 62-67.(IF=3.761, JCR2)

11. Jiliang Zhang, Zhenghong Zuo,Chengyong He, Jiali Cai, Yuqing Wang, Yixin Chen and ChonggangWang*.Effect of tributyltin on testicular development inSebastiscus marmoratus and the mechanism involved.Environmental Toxicology and Chemistry. (2009) Jul; 28(7):1528-35. (IF=2.809, JCR3)

12.  Ruixia Li, Zhenghong Zuo, Denglei Chen,Chengyong He, Rong Chen, Yixin Chen, Chonggang Wang*. 2011. Inhibition by polycyclic aromatic hydrocarbons of ATPase activities inSebastiscus marmoratus larvae: relationship with the development of early life stages.Marine Environmental Research(2011) 71(1): 86-90. (IF=2.276, JCR3)

联系方式:

址:福建省厦门市翔安区翔安南路,厦门大学公共卫生学院 (邮编361102)

话:0592-2880638

真:0592-2181578

Emailhecy@xmu.edu.cn