李少伟

发布时间:2011-08-12         浏览次数:6781


李少伟,博士  LI Shaowei, Ph.D.

教授,博士生导师Professor

结构疫苗学(Structural Vaccinology)

电话:+86-592-2880620

传真:+86-592-2181258

E-mailshaowei@xmu.edu.cn


简历 (Education and Work experience)

1998年,厦门大学生物化学专业,学士学位;

2003年,厦门大学生化与分子生物学/动物学专业,博士学位;

2003年,厦门大学生命科学学院讲师;

2006年,厦门大学生命科学学院副教授;

2011年,厦门大学生命科学学院/公共卫生学院教授、博士生导师。

B.S. Biochemistry, Xiamen University, 1998

Ph.D.Biochemistry&Molecular Biology/Zoology, Xiamen University, 2003

Lecturer,School of Life Sciences, Xiamen University, 2003

AssociateProfessor, School of Life Sciences, Xiamen University, 2006

Professor,School of Life Sciences/School of Public Health, Xiamen University, 2011


研究领域 (Research Area)

基因工程疫苗研究与开发

重要传染病病毒免疫表位的结构和功能研究

基于结构的分子模拟和分子设计

Research and development of recombinant human vaccine

Structural basis and functional implication for underlying immune epitopes of key infectious viruses

Structure-based molecular simulation and rational design for vaccine


代表性论文(Selected Publications)(* Corresponding author)

1.Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J,Ng MH, Hew CL, Li S*, Xia N*,Sivaraman J*.Structural basis for theneutralization of hepatitis E virus by a cross-genotype antibody.Cell Res. 2015 May;25(5): 604-20.

2.Li S, Zhang J, Xia N*. Lessons from hepatitis E vaccinedesign.Curr Opin Virol. 2015Apr;11:130-136.

3.Wang D, Li Z, Xiao J, Wang J, Zhang L, Liu Y, Fan F, XinL, Wei M, Kong Z, Yu H, Gu Y, Zhang J, LiS*, Xia N*. Identification of Broad-GenotypeHPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-NeutralizingAntibody.PLoS One. 2015 Apr23;10(4):e0123944.

4.Li SW, Zhao Q, Wu T*, Chen S, Zhang J, Xia NS. The developmentof a recombinant hepatitis E vaccine HEV 239.Hum Vaccin Immunother. 2015;11(4):908-14.

5.Gu Y, Cao F,Wang L, Hou W, Zhang J, Hew CL,Li S*, Yuan YA*, Xia N*. Structure of aNovel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-SpectrumAntibody A10F9 and Its Implication in Capsid Assembly. PLoS One. 2013 Apr19;8(4):e61314.

6.Yang C, Pan H, Wei M, Zhang X, Wang N, Gu Y, Du H, ZhangJ,Li S*, Xia N*.Hepatitis E virus capsid protein assembles in 4Murea in the presence of salts.ProteinSci. 2013 Mar;22(3):314-26.

7.Tang X, YangC, Gu Y, Song C, Zhang X, Wang Y, Zhang J, Hew CL,Li S*, Xia N*,Sivaraman J*. Structural basis for the neutralization and genotype specificityof hepatitis E virus. ProcNatlAcad Sci U S A. 2011 Jun 21;108(25):10266-71.Epub 2011 Jun 3.

8.Yu H,LiS*, Yang C, Wei M, Song C, Zheng Z, Gu Y, Du H, Zhang J, Xia N.Homology model and potential virus-capsid binding site of a putative HEVreceptor Grp78. J Mol Model. 2011May;17(5):987-95. Epub 2010 Jul 14.

9.Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H,Shih JW, Hew CL, Sivaraman J*, Xia N*. Dimerization of Hepatitis E Virus CapsidProtein E2s Domain is Essential for Virus-Host Interaction.PLoS Pathog. 2009 Aug;5(8):e1000537. Epub 2009 Aug 7.

10.Yang K,LiS*, He F, Zhang J, Wei M, Pan H, Yang C, Xiong J, Zhang J, Xia N.Expression and Purification of Soluble HIV-1 Envelope Glycoprotein gp160 Mutantfrom Saccharomyces Cerevisiae.JBiosci Bioeng. 2009 Jul;108(1):5-10.

11.Yan Y,LiS*, Yang C, Luo W, Wang M, Chen Y, Luo H, Wu T, Zhang J,  Xia N.Prediction of a common neutralizing epitope of H5N1 avian influenza virus by insilico molecular docking.ChineseScience Bulletin. 2008.53(1).

12.Li S, Zhang J, Li Y, Ou S, Huang G, He Z, Ge S, Xian Y, PangS, Ng M, Xia N*. A bacterially expressed particulate hepatitis E vaccine:antigenicity, immunogenicity and protectivity on primates. Vaccine.2005 Apr 22;23(22):2893-2901.

13.Li S, Zhang J, He Z, Gu Y, LiuR, Lin J, Chen Y, Ng M, Xia N*. Mutational analysis of essential interactionsinvolved in the assembly of hepatitis E virus capsid.J Biol Chem. 2005Feb 4;280(5):3400-6. Epub 2004 Nov 22.


荣誉、奖励及参加学术团体的情况(Honors and award):

2011年入选教育部新世纪优秀人才,2011年福建省杰出青年基金、2010年厦门市杰出青年基金;主持国家自然科学基金、“863”重点项目子课题、新药创制重大专项及滚动项目等课题;获得国家科技进步二等奖、国家技术发明二等奖、中国高校科技进步一等奖等;发表SCI论文40余篇,申请国家发明专利24项,国际发明专利12项,获得授权7项;为主研制出戊肝疫苗、宫颈癌疫苗、艾滋诊断试剂等新药。

WIPO-SIPO  Award for Chinese Outstanding Patented Invention (2012)

State   Technological Invention Award (2010)

State   Scientific and Technological Progress Award (2001)