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程通,CHENG TongPh.D.

教授,Professor

博士生导师

E-mailtcheng@xmu.edu.cn

Phone+86-592-2184113

 

研究领域(Research Area

主要开展病毒分子生物学、分子疫苗学和人源化动物模型研究。负责“国家传染病诊断试剂与疫苗工程技术研究中心”、“分子疫苗学与分子诊断学国家重点实验室”的病毒疫苗与感染模型研究组。目前研究方向包括:肠道病毒广谱中和表位与疫苗,水痘-带状疱疹病毒感染致病机制与新型疫苗,新型溶瘤病毒和人源化动物模型研究。以通讯或共同通讯作者发表SCI论文40余篇。已获得11项中国发明专利授权,和5项美国、欧盟、日本发明专利授权。


近年主要论文(*通讯作者Corresponding author):

1. Wang W#, Zheng Q#, Pan D#, Yu H#, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S*, Zhu H*, Zhou ZH*, Cheng T*, Xia N*. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nature Microbiology. 2020, 5(12):1542-52.

2. He M#, Xu L#, Zheng Q#, Zhu R#, Yin Z#, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH*, Cheng T*, Li S*, Xia N*. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host & Microbe. 2020, 27(2):249-61.

3. Zheng Q#, Zhu R#, Xu L#, He M#, Yan X#, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS*, Cheng T*, Li S*, Xia N*. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nature Microbiology. 2019, 4(1):124-33.

4. Yuan L#, Jiang J#, Liu X#, Zhang Y, Zhang L, Xin J, Wu K, Li X, Cao J, Guo X, Shi D, Li J, Jiang L, Sun S, Wang T, Hou W, Zhang T, Zhu H, Zhang J, Yuan Q, Cheng T*, Li J*, Xia N*. HBV infection-induced liver cirrhosis development in dual-humanized mice with human bone mesenchymal stem cell transplantation. Gut. 2019, 68(11):2044-56.

5. Zhu R#, Xu L#, Zheng Q#, Cui Y#, Li S#, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X*, Hong Zhou Z*, Cheng T*, Xia N*.Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Science Advances. 2018, 4(9):eaat7459.

6. Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T*, Zhou ZH, Yan X*, Xia N*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nature Communications. 2017, 8(1):505. 

7. Yuan L, Zhang Y, Liu X, Chen Y, Zhang L, Cao J, Li X, Wang M, Wu K, Zhang J, Liu G, Tang Q, Yuan Q*, Cheng T*, Xia N. Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice. Theranostics. 2019, 9(7):2115-28.

8. Yuan L, Liu X, Zhang L, Zhang Y, Chen Y, Li X, Wu K, Cao J, Hou W, Que Y, Zhang J, Zhu H, Yuan Q*, Tang Q*, Cheng T*, Xia N. Optimized HepaRG is a suitable cell source to generate human liver chimeric mouse model for chronic hepatitis B virus infection. Emerg Microbes Infect. 2018, 7(1):144.

9. Yuan L, Liu X, Zhang L, Li X, Zhang Y, Wu K, Cao J, Hou W, Zhang J, Zhu H, Yuan Q*, Tang Q*, Cheng T*, Xia N. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cell for the Chronic Hepatitis B Virus Infection. Frontiers in Microbiology. 2018, 9:908.

10. Li S, Armstrong N, Zhao H, Hou W, Liu J, Chen C, Wan J, Wang W, Zhong C, Liu C, Zhu H, Xia N, Cheng T*, Tang Q*. Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System. Viruses. 2018, 10(1):pii:E49.

11. Wang W, Fu W, Pan D, Cai L, Ye J, Liu J, Liu C, Que Y, Xia N, Zhu H*, Cheng T*. Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization. Virologica Sinica. 2017, 32(5):387-95.

12. Li S, Zhao H, Yang L, Hou W, Xu L, Wu Y, Wang W, Chen C, Wan J, Ye X, Liang Z, Mao Q*, Cheng T*, Xia N. A neonatal mouse model of coxsackievirus A10 infection for anti-viral evaluation. Antiviral Research. 2017, 144:247-55.

13. Wu Y, Zhu R, Xu L, Li Y, Li S, Yu H, Li S, Zhu H, Cheng T*, Xia N. A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against Enterovirus 71 and Varicella-Zoster Virus. Vaccine. 2017, 35(20):2728-35.

14. Yang L, Liu Y, Li S, Zhao H, Lin Q, Yu H, Huang X, Zheng Q, Cheng T*, Xia N. A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice. Vaccine. 2016, 34:5938-45.

15. Zhu R, Liu J, Chen C, Ye X, Xu L, Wang W, Zhao Q, Zhu H, Cheng T*, Xia N. A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice. Vaccine. 2016, 34:1589-96.

16. Ye X, Yang L, Jia J, Han J, Li S, Liu Y, Xu L, Zhao H, Chen Y, Li Y, Cheng T*, Xia N. Development of sandwich ELISAs that can distinguish different types of coxsackievirus A16 viral particles. Appl Microbiol Biotechnol. 2016, 100(6):2809-15.

17. Liu J, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, Zhu H, Cheng T*, Xia N. A monoclonal antibody-based VZV Glycoprotein E Quantitative Assay and Its Application on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol, 2015, 99(11):4845-53.

18. Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T*, Xia N. Protection against lethal Enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014, 4(5):498-513.