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  姓名:许零   

性别:女

政治面貌:九三学社

职称:教授

主要研究与教学领域:生物基功能材料的转化医学


个人简介

  

许零:博士,教授。多年来,主要从事高分子功能材料的合成、机理与应用基础研究。围绕烧创伤、溃疡等引起的皮肤修复问题,开展了一系列生物基伤口修复材料的转化医学研究,其中水凝胶创伤敷料、复合大孔聚多糖止血材料已进入产业化阶段,胶原基人工真皮处于产业化前期阶段。在水凝胶的相转变机制、细胞生物学效应及促血管生成机制等基础和应用研究方面取得了较好的成果,已发表SCI 论文六十余篇,获国家发明专利近十项。负责国家自然科学基金、科技支撑项目、国际科技合作项目等国家、省部级项目及企业合作项目四十余项。获福建百人、厦门海外高层次人才、北京市科学技术奖等奖励。

  

  

  

工作经历

2017. 9-          厦门大学公共卫生学院,教授

2007.12-2017.7     北京大学工学院能源与资源工程系,特聘研究员

2007.12-2017.7    北京大学前沿交叉学科研究院生物医用材料与组织工程研究中心,特聘研究员

2010.6-2010.9     日本日新电机有限公司新材料研究所,NEDO海外研究员

2006.1-2007.11    北京大学化学与分子工程学院,博士后

1993.8-2002.9       中国原子能科学研究院,研究实习员(1993.8-1998.9),助理研究员(1998.9-

2001.10-2002.9     日本原子力研究所,特别研究员

  

教育经历

2002.10-2005.9   日本东京工业大学,材料科学,博士

1999.9-2001.10   中国原子能科学研究院,核燃料循环与材料,硕士

1989.9-1993.7    北京化工大学,高分子材料,学士

  

  

  

主要成果

1.    Pu Xiao, Dong HanMaolin Zhai, Ling Xu*, Huibo Li .Comparison with adsorption of Re (VII) by two different γ-radiation synthesized silica-grafting of vinylimidazole/4-vinylpyridine adsorbents. Journal of Hazardous Materials, 2017, 324:711723.

2.    Pu Xiao, Ling Xu*, Xidong Wang, Zhibin Chang. Co-pyrolysis characteristics of coal and sludge blends using thermogravimetric analysis. Environmental Progress & Sustainable Energy. 2015, 34(6):1780–1789

3.    Yan Chen, Xiangmei Zhang, Qianyi Liu, Xidong Wang, Ling Xu*, Zuotai Zhang*    Facile and economical synthesis of porous activated semi-cokes for highly efficient and fast removal of microcystin-LR. Journal of Hazardous Materials, 2015, 299:325–332

4.    Yaqing Zhang, Xiangmei Zhang, Ling Xu*, Shicheng Wei* and Maolin Zhai. Radiation crosslinked collagen/dextran dermal scaffolds: effects of dextran on crosslinking and degradation   Journal of Biomaterials Science, Polymer Edition, 201526 (3): 162180.

5.    Xiangmei Zhang, Yaqing Zhang, Wenqiang Chen, Ling Xu*, Shicheng Wei,Yufeng Zheng, Maolin Zhai. Biological Behavior of Fibroblast on Contractile Collagen Hydrogel Crosslinked by γ-Irradiation.  Journal of Biomedical Materials Research: Part A2014102 2669–2679

6.    Jian Sun, Zhimin Chen, Mengyi Ge, Ling Xu*, Maolin Zhai. Selective adsorption of Hg(II) by γ-radiation synthesized silica-graft-vinyl imidazole adsorbent.  Journal of Hazardous Material 2013, 244-245: 94-101(corresponding author)

7.    Xiangmei Zhang, Ling Xu*, Shicheng Wei, Maolin Zhai, Jiuqiang Li. Stimuli Responsive Deswelling of Radiation Synthesized Collagen Hydrogel in Simulated Physiological Environment. Journal  of  Biomedical  Materials Research: Part A DOI10.1002/jmb.a.34525 (corresponding author)

8.    Jian Sun, Ling Xu*, Mengyi Ge, Maolin Zhai. Radiation Degradation of Microcrystalline Cellulose in Solid Status. Journal of Applied Polymer Science 2013,127:1630-1636 (corresponding author)

9.    Ying Zhou, Ling Xu*, Shicheng Wei, Maolin Zhai. Radiation Synthesis of Gelatin/CM-chitosan /β-tricalcium phosphate Composite Scaffold for Bone Tissue Engineering. Materials Science and Engineering C 2012, 32: 994–1000 (corresponding author)

10.   Xiangmei Zhang, Ling Xu*, Xin Huang, Shicheng Wei, Maolin Zhai. Structural Study and Preliminary Biological Evaluation on the Collagen Hydrogel Crosslinked by γ-ray Irradiation. Journal  of  Biomedical  Materials Research: Part A 2012, 100A: 2960-2969. (corresponding author)

11.   Ying Zhou, Yinghui Zhao, Lu Wang, Ling Xu*, Maolin Zhai, Shicheng Wei*. Radiation synthesis and characterization ofnanosilver/gelatin/carboxymethyl chitosan hydrogel. Radiation Physics and Chemistry  2012, 81: 553-560 (corresponding author)

12.   Yinghui Zhao, Ying Zhou, Ling Xu*, Lu Wang, Shicheng Wei. Electrospinning of silver nanoparticles / carboxymethyl-chitosan / poly (vinyl alcohol) nanofibers for antibacterial applications. Applied Surface Science 2012, 258: 8867– 8873 (corresponding author) 

13.   Long Zhao, Jian Sun, Yinghui Zhao, Ling Xu*, Maolinzhai. Removal of Hazardous Metal Ions from Wastewater by Radiation Synthesized Silica-graft-Dimethylaminoethyl Methacrylate Adsorbent. Chemical Engineering Journal 2011, 170: 162–169 (corresponding author)

14.   Ling Xu*, Jian Sun, Long Zhao. Co-grafting of Acrylamide and Vinyl Imidazole onto EB Preirradiated Silanized Silica Gel. Radiation Physics and Chemistry 2011, 80: 1268-1274 (corresponding author)

15.   Chao Yang, Xiaomian Wu, Yinghui Zhao, Ling Xu*, Shicheng Wei. Nanofibrous Scaffold Prepared by Electrospinning of Poly(vinyl alcohol)/Gelatin Aqueous Solutions. Journal of Applied Polymer Science 2011, 121: 3047–3055. (corresponding author)

16.   Min Wang, Ling Xu*, Cancan Li, Zhiying Yue, Maolin Zhai, Jiuqiang Li. Antipolyelectrolyte Swelling of Amphiphilic Hydroxypropyl Methylcellulose Phthalate Gels. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2010, 356: 89–96 (corresponding author)

17.   Rui Fang, Enwei Zhang, Ling Xu*, Shicheng Wei. Electrospun PCL/PLA/HA Based Nanofibers as Scaffold for Osteoblast-like Cells. Journal of Nanoscience and Nanotechnolody 2010, 10 (11): 7747-7751. (corresponding author)

18.   Chao Yang, Ling Xu*, Ying Zhou, Xiangmei Zhang, Xin Huang, Min Wang, Ye Han, Maolin Zhai, Shicheng Wei, Jiuqiang Li. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers 2010, 82: 1297-1305. (corresponding author)

19.   Jingyi Qiu, Ziyue Wang, Huibo Li, Ling Xu*, Jing Peng , Maolin Zhai, Chao Yang, Jiuqiang Li, Genshuan Wei. Adsorption of Cr(VI) Using Silica-based Adsorbent Prepared by Radiation Induced Grafting. Journal of Hazardous Material 2009, 166: 270-276. (corresponding author)

20.   Ling Xu*, Xin Li, Maolin Zhai, Jing Peng, Jiuqiang Li, Genshuan Wei. Specific F- Binding to Phenyl Ring of Aromatic Polymer. Journal of Fluorine Chemistry. 2009, 130: 959–965. (corresponding author)

21.   Ling Xu, Maolin Zhai, Ling Huang, Jing Peng, Jiuqiang Li, Genshuan Wei. Specific Stimuli Responsive Antipolyelectrolyte Swelling of Amphiphilic Gel Based on Methacryloxyethyl Dimethyloctane Ammonium Bromide. Journal of Polymer Science, Part A. Polymer Chemistry 2008, 46: 473–480.

22.   Ling Xu, Xin Li, Maolin Zhai, Ling Huang, Jing Peng, Jiuqiang Li, Genshuan Wei. Ion-specific Swelling of Poly (styrene sulfonic acid) Hydrogel. Journal of Physical Chemistry B 2007, 111: 3391-3397.

23.   Ling Xu, Eisuke Yokoyama, Mitsuru Satoh, “Interactions of Poly(4-vinyl phenol) with Hydrophobic Ions in Dispersion System”, Colloids and Surfaces A: Physicochemical and Engineering Aspects 296 (1-3) (2007) 277-284.

24.   Ling Xu, Zhiying Yue, Maolin Zhai, Fumio Yoshii, Noriaki Seko, Jing Peng, Genshuan Wei, Jiuqiang Li. Radiation Effects of Hydroxypropyl Methylcellulose Phthalate in Aqueous System. Nuclear Instruments and Methods in Physics Research B 265 (2007) 394–398.

25.   Ling Xu, Kazunori Iwata, Shingo Kobayashi, Takashi Ishizone, Mitsuru Satoh. Salt resistivity of poly (4-vinyl benzoic acid) gel. Colloid and Polymer Science 2007, 285: 485–489.

26.    Ling Xu, Hiroko Watando, Mitsuru Satoh, Effects of Chemical Modifications on the Swelling Behaviors of Poly (4-vinyl phenol) Gel, Colloid and Polymer Science 2006, 284 (8): 862-870.

27.   Ling Xu, Eisuke Yokoyama, Mitsuru SatohSpecific Interactions of Poly (4-vinyl phenol) Gel with Cationic and Anionic Surfactants, Langmuir 2005,21: 7153-7160.

28.   Ling Xu, Eisuke Yokoyama, Hiroko Watando, Rei Okuda-Fukui, Susumu Kawauchi, Mitsuru Satoh, Specific Swelling Behaviors of Poly (4-vinyl phenol) Gels in Tetraalkylammonium Chloride Solutions, Langmuir 2004, 20: 7064-7069.

29.   Ling Xu, Naotsugu Nagasawa, Fumio Yoshii, Tamikazu Kume, Synthesis of Hydroxypropyl Methylcellulose Phthalate Gels in Organic Solvents by Radiation Crosslinking, Journal of Applied Polymer Science 92 (2004) 3002-3007.

30.   Ling Xu, Naotsugu Nagasawa, Fumio Yoshii, Tamikazu Kume, Syntheses of Hydroxypropyl Methylcellulose Phthalate Hydrogels in Na2CO3 aqueous solution with Electron Beam Irradiation, Journal of Applied Polymer Science 2003, 89: 2123-2130.

31.   Long Zhao, Ling Xu. Treatment of mercury(II)-containing waste water and synthisis of mercury(II) ions adsorbents. (Japan/PCT) Applying No: PCT/JP2010-69831, 2010.11.8.

32.   许零,周英,翟茂林。一种纳米银抗菌水凝胶及其制备方法。中国发明专利CN201210143562.2.

33.   许零,王多祥,黄凌,翟茂林. 一种超细微晶纤维素及其制备方法. 中国发明专利(ZL 2009 1 0077402.0.

34.   许零,杨超. 一种明胶海绵及其制备方法. 中国发明专利(ZL 2009 1 0087274.8.

53. 王家驹,许零,罗志武,李涛. 水凝胶复合型创伤敷料及其辐射合成方法. 中国发明专利(ZL 00107403.2).

54. 翟茂林,许零,彭静,魏根拴. 含天然高分子的水凝胶及其辐射制备方法. 中国发明专利(ZL 2006 1 0113539.3      .

  

  

负责的主要课题

序号

起讫时间

本人承担任务

1

生物基伤口修复材料的环境友好高效制备及产业化(第四批福建百人)

福建省组织部

2015.1-

项目负责人

2

Modulation of mechanical property and angiogenic potential of   Collagen/CM-Chitason scaffolds through cross-linking and heparin   incorporation

国际原子能机构

2015.8-2018.7

项目负责人

3

辐射交联胶原凝胶的细胞生物学效应(国家自然科学基金)

国家自然科学基金委

2012.1-2014.12

项目负责人

4

工业固废综合利用检测标准体系及检测标准研究(科技支撑计划)

科技部

2011.1-2013.12

项目负责人

5

辐射交联胶原支架在骨外露创面修复中的作用及其机制研究(深圳市战略性新兴产业发展专项资金)

深圳市

2012.9-2014.9

项目负责人

6

辐射制备胶原凝胶及其生物学效应研究(深圳市基础研究计划)

深圳市

2012.1-2014.12

项目负责人

7

硅胶与PE/PP基无纺布的表面改性及其对重金属离子的选择性吸附研究(中国-土耳其政府间科技合作项目)

科技部

2010.1-2011.1

项目负责人

8

利用电子束辐照接枝技术合成环境功能材料(NEDO海外研究员项目)

日本NEDO

2010.6-2010.9

项目负责人