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陈洪敏 教授/博士生导师



通信地址:厦门大学分子疫苗学和分子诊断学国家重点实验室 厦门大学分子影像暨转化医学研究中心  361102

电话/传真0592-2880647

电子邮箱:  hchen@xmu.edu.cn

课题组主页:chm.xmu.edu.cn

 

主要研究方向在分子影像和纳米医学领域。多年来主要围绕“分子探针多模态影像与协同治疗的高效融合”关键科学问题,致力于功能影像探针在癌症诊断与治疗的研究,取得了一系列创新性的、并具有较高临床应用前景的重要研究成果:1) 高效融合放射治疗和光动力治疗,构建了无机闪烁体增敏体系,实现了低辐射剂量有效抑制深层原位肿瘤;2) 研究制备了“钆稳定”多功能磁共振成像探针。至今发表SCI学术论文40篇,SCI他引>1900次。现担任Chem. Soc. Rev., J. Am. Chem. Sci., Adv. Mater.等国际学术期刊的审稿人。国家级人才项目评审专家。

     荣誉与获奖情况:

  • 国家级人才项目

  • 福建省引进高层次人才-境外B

  • 厦门大学南强青年拔尖人才A类人才

  • UGA Postdoc Research Award

  • 中国科学院院长奖优秀奖

  • 中国科学院优秀毕业生

     

    研究兴趣:功能影像探针 (Functional imaging Probes)

    1. Nanophorsphors-mediated X-ray induced photodynamic therapy

    2. Metal-encapsulated carbon dots for clinical magnetic resonance imaging

    3. Tumor-microenvironments-stimulated nanotheranostics

    4. Near infrared II (NIR II) imaging agents

    在研项目:

    国家级人才项目、国家自然科学基金面上项目、 国家重点研发计划项目干细胞及转化研究、厦门市科技计划项目、厦门大学南强青年拔尖人才A类人才、厦门大学校长基金培育项目、横向项目

    主要代表性论著(自2017年加入厦门大学。#共同一作,*通讯作者,&本科生):

    11. Wenjing Sun, Li Luo, Yushuo Feng, Yuting Cai, Yixi Zhuang, Rong-Jun Xie, Xiaoyuan Chen,* Hongmin Chen*. Aggregation-Induced Emission Gold Clustoluminogens for Enhanced Low-Dose X-ray-Induced Photodynamic Therapy, Angew. Chem. Int. Ed. 2019, In Press. DOI: 10.1002/anie.201908712 (IF 12.257).

    10. Li Luo,# Wenjing Sun,# Yushuo Feng, Ruixue Qin, Jinghui Zhang, Dandan Ding, Tianhang Shi, Xiangmei Liu, Xiaoyuan Chen,*, Hongmin Chen*, Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X-Ray-Induced Photodynamic Therapy of Tumors, ACS Appl. Mater. Interfaces Accept (IF 8.456).

    9. Wenjing Sun, Zijian Zhou, Guillem Pratx, Xiaoyuan Chen*, Hongmin Chen*, Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated Tumors: From Concept to Biomedical Applications, Theranostics 2020, 10, 1296 (IF 8.063).

    8. Wen Jiang#, Lei Yin#, Hongmin Chen#, Amy Victoria Paschall, Liuyang Zhang, Wenyan Fu, Weizhong Zhang, Trever Todd, Kevin Shengyang Yu, Shiyi Zhou, Zipeng Zhen, Michael Bultler, Li Yao, Feng Zhang, Ye Shen, Zibo Li, Amelia Yin, Hang Yin, Xianqiao Wang, Fikri Avci, Xiaozhong Yu,* Jin Xie*. NaCl Nanoparticles as a Cancer Therapeutic, Adv. Mater. 2019, 31, 1904058 (IF 25.809).

    7. Yushuo Feng, Dandan Ding, Wenjing Sun, Yuwei Qiu, Li Luo, Tianhang Shi, Shanshan Meng, Xiaoyuan Chen*. Hongmin Chen*, Magnetic Manganese Oxide Sweetgum-ball Nanospheres with Large Mesopores Regulate Tumor Microenvironments for Enhanced Tumor Nanotheranostics, ACS Appl. Mater. Interfaces 2019, 11, 37461 (IF 8.456).

    6. Yuwei Qiu, Dandan Ding, Wenjing Sun, Yushuo Feng, Doudou Huang, Sicheng Li&, Shanshan Meng, Qingliang Zhao*, Li-Jun Xue*, Hongmin Chen,* Hollow mesoporous carbon nanospheres for imaging-guided light-activated synergistic thermo-chemotherapy. Nanoscale2019, 11, 16351 (IF 6.97).

    5. Wenjing Sun, Tianhang Shi, Li Luo, Xiaomei Chen, Peng Lv, Ying Lv, Yixi Zhuang, Jinjie Zhu&, Gang Liu, Xiaoyuan Chen*, Hongmin Chen*, Monodisperse and Uniform Mesoporous Silicate Nanosensitizers Achieve Low-Dose X-Ray-Induced Deep-Penetrating Photodynamic Therapy, Adv. Mater. 2019, 31, 1808024 (IF 25.809).

    4. Ying Lv#, Dandan Ding#, Yixi Zhuang*, Yushuo Feng, Junpeng Shi, Hongwu Zhang, Tian-Liang Zhou, Hongmin Chen*, Rong-Jun Xie*, Chromium-Doped Zinc Gallogermanate@Zeolitic Imidazolate Framework-8: A Multifunctional Nanoplatform for Rechargeable In Vivo Persistent Luminescence Imaging and pH-Responsive Drug Release, ACS Appl. Mater. Interfaces 2019, 112, 1907 (IF 8.456).

    3. Hongmin Chen*, Yuwei Qiu, Dandan Ding, Huirong Lin, Wenjing Sun, Geoffrey D. Wang, Weicheng Huang, Weizhong Zhang, Daye Lee, Gang Liu*, Jin Xie*, Xiaoyuan Chen*, Gadolinium-Encapsulated Graphene Carbon Nanotheranostics for Imaging-Guided Photodynamic Therapy, Adv. Mater. 2018, 30, 1802748 (IF 25.809).

    2.   Hongmin Chen#, Xilin Sun#, Geoffrey D. Wang, Koichi Nagata, Zhonglin Hao, Andrew Wang, Zibo Li, Jin Xie*, Baozhong Shen*, LiGa5O8:Cr-based theranostic nanoparticles for imaging-guided X-ray induced photodynamic therapy of deep-seated tumors, Mater. Horiz. 2017, 4, 1092 (IF 14.356).

    1. Hongmin Chen, Weizhong Zhang, Guizhi Zhu, Jin Xie*, Xiaoyuan Chen*, Rethinking cancer nanotheranostics, Nature Rev. Mater. 2017, 2, 17024 (IF 74.449).