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申河清 教授 环境医学课题组组长

E-mail: hqshen@iue.ac.cn; hqshen@xmu.edu.cn

http://www.researcherid.com/rid/H-9338-2013https://orcid.org/0000-0002-6544-4919

 

兼职和社会服务: Environment International编委(2013-)HMGU和赫姆霍兹环境健康研究生院(HELENA)博士研究生合作导师(2016-)、巴基斯坦COMSATS伊斯兰堡大学博士研究生合作导师(2015-)、环境科学学会环境医学和健康分会委员(2013-)、国际科联亚太地区分会(ICSU ROAP)国际项目城市环境健康和福祉学委员会委员、浙江省海产品健康危害因素关键技术研究重点实验室学术委员(2014-)、中国毒理学会呼吸毒理专业委员会常委(2018-)、中科院城市环境研究所兼职研究员(2019 -)。

讲授课程:卫生化学、生活中的毒理学、全球卫生概论、环境暴露与公众健康等课程。


一、学习和工作经历

2019-至今    厦门大学公共卫生学院 教授

2009-2019    中国科学院城市环境研究所 研究员

2006-2009    丹麦哥本哈根大学医院 博士后

2005-2006    慕尼黑赫姆霍茨中心(HMGU) 博士后

2002-2005    德国慕尼黑工业大学(TUM) 化学博士

1994-1997    中国科学院大连化学物理研究所   化学硕士

1997-2001    大连民族学院  讲师

1991-1994    长治煤气公司  技术员

1987-1991    太原理工大学  化学学士


二、主要研究方向

从事环境污染物的暴露和健康效应(环境医学)研究。主要是(1)环境污染的检测和生物监测;(2)系统流行病学和;(3)系统毒理学。


三、科研成果

发表SCI论文100多篇,授权专利3件。主要学术成果:(1)提出并完善了用人群污染物内暴露剂量作为分类器来筛选污染因素的效应标志物;建立分子流行病学概念框架下基于污染物生物监测、代谢组效应和疾病风险(即meet-in-metabolite analysis)的研究范式,用来揭示存在于暴露-不良健康结局发生和发展连续体之间的流行病学黑箱问题;(2)建立和完善了婴幼儿人群纸尿裤尿液的内暴露监测方法,并用于0-2岁儿童内分泌干扰物暴露评估、毒物(药物)代谢动力学和健康效应研究。

  1. 论文

2020

  1. Jinjin Jiang, Yang Li, Shuang Liang, Baiyang Sun, Yanfeng Shi, Qing Xu, Jie Zhang, Heqing Shen, Junchao Duan, Zhiwei Sun. Combined exposure of fine particulate matter and high-fat diet aggravate the cardiac fibrosis in C57BL/6J mice. J Hazardous Materials. 2020, 391(5), 122203

  2. Jingyi Zhang, Shuang Liang, Ruihong Ning, Jinjin Jiang, Jie Zhang, Heqing Shen, Rui Chen, Junchao Duan, Zhiwei Sun. PM2.5-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis. Environ Int 2020, 136, 105444

  3. Nabgha-e-Amen, Syed Ali Musstjab Akber Shah Eqani, Faiza Khuram, Ambreen Alamdar, Ayesha Tahir, Syed Tahir Abbas Shah, Arshan Nasir, Sundus Javed, Nazia Bibi, Alamdar Hussain, Hifza Rasheed, Heqing Shen. Environmental exposure pathway analysis of trace elements and autism risk in Pakistani children population. Sci Total Environ 2020, 712(10 April), 136471

  4. Meiping Tian, Benhua Zhao, Francis L. Martin, Camilo L.M. Morais, Liangpo Liu, Qingyu Huang, Jie Zhang, Heqing Shen. Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure.Environ Int 2020, 134, 105313

2019

  1. Meiping Tian, Liangpo Liu, Jie Zhang, Qingyu Huang, Heqing Shen. Positive association of low-level environmental phthalates exposure with sperm motility was mediated by DNA methylation: a pilot study. Chemosphere 2019, 220, 459-467

  2. Qingyu Huang, Liangpo Liu, Yan Wu, Xiaofei Wang, Lianzhong Luo, Bingru Nan, Jie Zhang, Meiping Tian, Heqing Shen. Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environ Int 2019, 132, 105066

  3. Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarrob, Jie Zhang, An Pan. Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men. Environ Int 2019, 129, 354363

  4. 吴衍,张西,张洁,张雪芹,申河清. 基于液相色谱质谱联用技术的妊娠期糖尿病患者脐带血代谢组学网络分析.色谱.2019378),897-903;DOI:10.3724/SP.J.1123.2019.02006

  5. Xueyan Li, Liangpo Liu, Heng Wang, Xueqin Zhang, Tonghu Xiao, Heqing Shen*. Phthalate exposure and cumulative risk in a Chinese newborn population. Environ Sci Pollution Res 2019, https://doi.org/10.1007/s11356-019-04216-z

  6. Meiping Tian, Xi Zhang, Liangpo Liu, Francis L. Martin, Heng Wang, Jie Zhang, Qingyu Huang, Xiaofei Wang, Heqing Shen*. Phthalate side-chain structures and hydrolysis metabolism associated with steroidogenic effects in MLTC-1 Leydibg cells. Toxicology Letters 2019, 308 (15 June), 56-64.

  7. Ambreen Alamdar, Meiping Tian, Qingyu Huang, Xiaoyan Du, Jie Zhang, Liangpo Liu, Syed Tahir Abbas Shah, Heqing Shen. Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. Ecotoxicol Environ Safety 2019, 170, 513–520

12.   Meiping Tian, Qingyu Huang, Heng Wang, Francis L Martin, Liangpo Liu, Jie Zhang, Heqing Shen. Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells. Reproductive Toxicology 2019, 83, 54-62

 

2018

  1. Qingyu Huang, Dayu Hu, Xiaofei Wang, Yahong Chen, Yan Wu, Lu Pan, Hongyu Li, Jie Zhang, Furong Deng, Xinbiao Guo, Heqing Shen. The modification of indoor PM2.5 exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis. Environ Int 121, 2018, 1243-52

  2. Yan Wu, Jie Zhang, Siyuan Peng, Xiaofei Wang, Lianzhong Luo, Liangpo Liu, Qingyu Huang, Meiping Tian, Xueqin Zhang, Heqing Shen,Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium. Environ Int121, 2018, 1227-34

  3. Zhong-Min Li, David Hernandez-Moreno, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm, Meri De Angelis; Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones, Endocrinology 2018, 159(10), 3473–81

  4. Meiping Tian, Liangpo Liu, Heng Wang, Xiaofei Wang, Francis L. Martin, Jie Zhang, Qingyu Huang, and Heqing Shen, Phthalates Induce Androgenic Effects at Exposure Levels That Can Be Environmentally Relevant in Humans. Environ Sci & Technol Letters 2018 5 (5), 232-236 DOI: 10.1021/acs.estlett.8b00138

  5. Zhong-Min Li, Florian Giesert, Daniela Vogt-Weisenhorn, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm, Meri De Angelis. Determination of thyroid hormones in placenta using isotope-dilution liquid chromatography quadrupole time-of-flight mass spectrometry. J. Chromatogra. A, 2018 ,1534, 85–92

  6. Liu, L.J., Yang, X., Wang, M.Q., Long, Y., Shen, H.Q., Nie, Y., Chen, L.X., Guo, H.Y., Jia, F., Nelson, J., Song, G.Z., Frank, A., Welles, S. and Haas, C.N. (2018) Climate Change, Air Quality and Urban Health: Evidence from Urban Air Quality Surveillance System in 161 Cities of China 2014. J Geosci Environ Protect, 6, 117-130. https://doi.org/10.4236/gep.2018.63011

  7. Eqani, Syed Ali Musstjab Akber Shah; Tanveer, Zafar Iqbal; Qiaoqiao, Chi; et al. Occurrence of selected elements (Ti, Sr, Ba, V, Ga, Sn, Tl, and Sb) in deposited dust and human hair samples: implications for human health in Pakistan. Environ Sci Pollution Res, 2018, 25, 13,12234-45

  8. Du X, Tian M, Wang X, Zhang J, Huang Q, Liu L, Shen H*. Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water.Environ Pollut. 2018, 234 (7):590-600.

  9. Muhammad Sohail, Syed Ali Musstjab Akber Shah Eqani, Joel Podgorski, Avit Kumar Bhowmik, Adeel Mahmood, Nadeem Ali, Tara Sabo-Attwood, Habib Bokhari, Heqing Shen. Persistent organic pollutant emission via dust deposition throughout Pakistan: Spatial patterns, regional cycling and their implication for human health risks. Sci Total Environ, 2018, 618(15):829-837

     

2017

  1. Podgorski JE, Eqani SAMAS, Khanam T, Ullah R, Shen H, Berg M, Extensive arsenic contamination in high-pH unconfined aquifers in the Indus Valley. Sci. Adv.3, e1700935 (2017).

  2. Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia, Heqing Shen*. Phthalate metabolites related to infertile biomarkers and infertility in Chinese men. Environ Pollut. 2017 Aug 12;231(Pt 1):291-300. doi: 10.1016/j.envpol.2017.08.018

  3. Heng Wang, Liangpo Liu, Syed Ali Musstjab Akber Shah Eqani, Heqing Shen*. Infant Exposure to Bisphenol A can be Quantitatively Assessed by a Simply Improved High-Performance Liquid Chromatography Tandem Mass-Spectrometry Method. Anal Sci2017, 33 (7) :777-781.

  4. Heng Wang, Liangpo Liu, Jianyue Wang, Zhendong Tong, Jianbo Yan, Tongjie Zhang, Ying Qin, Tingting Jiang, Jianwen She, Heqing Shen*. Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage: Preliminary results from a Daishan birth cohort. Sci Total Environ, 2017, 601-602(1): 1733-1742

  5. Xiaofei Wang, Shoufang Jiang, Ying Liu, Xiaoyan Du, Weibing Zhang, Jie Zhang, Heqing Shen*. Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats. Sci Total Environ, 2017, 592: 41-50.

  6. Xiaofei Wang, Liangpo Liu, Xiaoyan Du, Qingyu Huang, Meiping Tian, Weibing Zhang, Jie Zhang, Heqing Shen*. Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans. Environ Pollut, 2017, 229:168-176.

  7. WANG Xiao-FeiJIANG Shou-FangZHANG Ling-YiLIU YingDU Xiao-YanZHANG Wei-BingZHANG JieSHEN He-Qing*. Study on Reproductive Toxicity of Fine Particulate Matter by Metabonomics. Ch J Anal Chem, 2017,45(5), 633-640.

  8. Alamdar A, Xi, G., Huang, Q., Tian M., SAMAS Eqani, Shen H*. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. Toxicol Applied Pharmacol, 326 (2017) 714.

  9. Ali N, Eqani SAMAS, Shahzad K, Rashid MI, Ismail IMI, Shen H*, Ehtisham N, Talal A. Currently used organophosphate and brominated flame retardants in the environment of China and other developing countries (2000-2016). Environ Sci Pollution Res, 2017, 24, 18721-18741

  10. Alamdar A, Eqani SAMAS,Hanif N, Ali SM, Fasola M, Bokhari H, Katsoyiannis IA,Shen H*. Human exposure to trace metals and arsenic via consumption of fish from river Chenab, Pakistan and associated health risks. Chemosphere 168 (2017) 1004-1012

2、课题

  1. 国家自然科学基金委员会,面上项目,21777157,砷的睾丸毒作用模式和男性不育替代终点标志物研究,2018-01-2021-1230万元,在研,主持

  2. 科技部,国家重点研发计划重点专项,2017YFC0211602,大气污染致呼吸和心血管系统毒性表型及毒作用模式研究(大气污染对呼吸和心血管系统健康影响的早期识别技术:课题2),460万,2017-072020-12,在研,主持   

  3. 国家自然科学基金委员会,重大研究计划培育项目,91543113,基于定组人群追踪的大气细颗粒物暴露组学及代谢效应标志物研究,2016-012018-1276万,结题,主持

  4. 国家自然科学基金委员会,国际(地区)合作与交流项目,21311130119,全氟辛烷类污染物干扰睾丸支持细胞和睾丸间质细胞内分泌功能的研究,2013-042015-0312万,结题,主持

  5. 国家自然科学基金委员会,面上项目,21177123,育龄男性全氟烷烃类化合物暴露和精子DNA甲基化关系研究,2012-012015-1260万,结题,主持

  6. 厦门市科技局,厦门市科技计划项目,3502Z20122003,邻苯二甲酸酯类物质污染对厦门市妇女及幼童的影响及防控对策研究,2011-092013-0920万,结题,主持

  7. 教育部,第39批 “留学回国人员科研启动基金”,用胶质尿片采集尿液作为婴幼儿易代谢内分泌干扰物测定的可行性研究2010-082012-084万,结题,主持

  8. 中国科学院,中国科学院百 人计划项目, 09i4061a70,环境污染物的人群暴露与健康,2009-042012-04300万,结题,主持