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赵西林 教授/博导

病原微生物与抗感染治疗课题组组长

联系电话:0592-2880630  邮箱: zhaox5@xmu.edu.cn

主要学习经历:

2003/01,英国东英吉利大学(UEA)约翰因茵尼斯中心(John Innes Centre)分子微生物学博士

1990/12,南开大学分子生物学研究所,分子生物学硕士

1988/07,南开大学生物学系,生物化学学士

科研工作经历:

2021.11至今,厦门大学公共卫生学院南强重点岗位教授

2021.07至今,美国新泽州立罗格斯(Rutgers)大学、新泽西医学院(NJMS)、微生物、生物化学与分子遗传学系兼职(adjunct)副教授

2013.072021.06,美国新泽州立罗格斯(Rutgers)大学、新泽西医学院(NJMS)、微生物、生物化学与分子遗传学系副教授

20122021.10,厦门大学公共卫生学院双聘/讲座教授

2010-2021.06,美国新泽西公共健康研究所(PHRI)首席研究员(Principal Investigator

20062013.06,美国新泽西医科与牙医大学(UMDNJ)新泽西医学院(NJMS)微生物与分子遗传学系助理教授、副教授

20032010:美国新泽西公共健康研究所(PHRI)副研究员(Research Associate Member

19942001:美国纽约公共健康研究所(PHRI)研究科学家(Research Scientist

19911993:南开大学分子生物学研究所研究实习员、助理研究员

主要研究方向:

1)菌应急应答及活性氧介导的程序性凋亡

2CRISPR介导的抗生素耐药逆转

3)新抗生素及广谱增效剂

4)肠道菌群及细菌感染的无创、实时体内成像

科研成果:

1.代表性论文

1.Zhang, Z, D. Xu, J. Fang, D. Wang, J. Zeng, X. Liu, S. Hong, Y. Xue, X. Zhang*, X. Zhao* (2021). In situ live imaging of gut microbiota. mSphere 6 (5): e00545-21.

2.J. Zeng, L. Wu, Z. Liu, Y. Lv, J. Feng, W. Wang, Y. Xue, D. Wang, J. Li*, Xilin Zhao*. (2021). Gain-of-function mutations in acid stress response (evgS) protect Escherichia coli from killing by gallium nitrate, an antimicrobial candidate. Antimicrob. Agents Chemother. 65 (3): e01595-20 (https://doi.org/10.1128/AAC.01595-20).

3.Hong, Y., Q Li, Q. Gao, J. Xie, H. Huang, K. Drlica, X. Zhao* (2020). Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing. J Antimicrob Chemother 75 (3): 576-585. doi: 10.1093/jac/dkz485.

4.Y. Hong, J. Zeng, X. Wang, K. Drlica, X. Zhao* (2019). Post-stress bacterial cell death mediated by reactive oxygen species. Proc. Natl. Acad. Sci. U.S.A. 116 (20): 10064-10071.

5.G Luan, Y Hong, K Drlica, X Zhao* (2018). Suppression of reactive-oxygen-species accumulation accounts for paradoxical bacterial survival at high quinolone concentration. Antimicrobial Agents and Chemotherapy. 62 (3) pii: e01622-17. doi: 10.1128/AAC.01622-17.

6.Y Hong, L Li, G Luan, K Drlica, X Zhao* (2017). Contribution of reactive oxygen species to thymineless death in Escherichia coli. Nature microbiology 2 (12), 1667.

7.Mi H, Wang D, Xue Y, Zhang Z, Niu J, Hong Y, Drlica K, Zhao X*.(2016). Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing. Antimicrob Agents Chemother60(8):5054-8.

8.Long Q, Du Q, Fu T, Drlica K, Zhao X*, Xie J*. (2015). Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis. Antimicrobial Agents and Chemotherapy 59: 1782-5.

9.Zhao X, Hong Y, Drlica K. (2015). Moving forward with reactive oxygen species involvement in antimicrobial lethality. J. Antimicrob. Chemother. 70: 639-42.

10.Li L, Hong Y, Luan G, Mosel M, Malik M, Drlica K, Zhao X* (2014). Ribosomal elongation factor 4 promotes cell death associated with lethal stress. mBio 5 (6): e01708.

11.Zhao X*, Drlica K. (2014) Reactive oxygen species and the bacterial response to lethal stress. Curr. Opin. Microbiol. 21C: 1-6.

12.Malik M,Li L, Zhao X*, Kerns RJ, Berger JM, and Drlica K*. (2014). Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. J. Antimicrob. Chemother. 69: 3227-35.

13.Yuan X, Liu Y, Bai C, Luo Y, Wang R, Wang R, Cai Y, Zhao X* (2014). Mycoplasma pneumoniae infection is associated with subacute cough. Eur Respir J. 43: 1178-81.

14.Dorsey-Oresto A, Lu T, Mosel M, Wang X, Salz T, Drlica K, Zhao X* (2013). YihE kinase is a central regulator of programmed cell death in bacteria. Cell Reports 3 (2): 528-537.

15.Mosel M, Li L, Drlica K, Zhao X* (2013). Superoxide-mediated protection of Escherichia coli from antimicrobials. Antimicrob Agents Chemother. 57: 5755-9.

16.Liu Y, Liu X, Qu Y, Wang X, Li L, Zhao X* (2012). Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. Antimicrob Agents Chemother 56: 6048-50.

17.Liang B, Bai N, Cai Y, Wang R, Drlica K, Zhao X* (2011). Mutant prevention concentration- based pharmacokinetic/pharmacodynamic indices as dosing targets for suppressing the enrichment of levofloxacin-resistant subpopulations of Staphylococcus aureus. Antimicrob Agents Chemother 55: 2409-12.

18.Wu X, Wang X, Drlica K, Zhao X* (2011). A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. PLoS ONE 6 (8): e23909.

19.Wang X, Zhao X* (2009). Contribution of oxidative damage to antimicrobial lethality. Antimicrob Agents Chemother 53:1395-402.

20. Drlica K, Malik M, Kerns RJ, Zhao X (2008). Quinolone-mediated bacterial death. Antimicrob Agents Chemother 52: 385-92.

21. Cui, J., Liu, Y., Wang, R., Tong, W., Drlica, K., Zhao, X*. (2006). The mutant selection window in rabbits infected with Staphylococcus aureus. J. Infect. Dis. 194: 1601-8.

22. Liu, Y., Cui, J., Wang, R., Wang, X., Drlica, K., Zhao, X*. (2005). Selection of rifampicin- resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquistion of resistance. J. Antimicribial Chemotherapy.56: 1172-1175.

23. Zhao X, Drlica K (2002). Restricting the selection of antimicrobial-resistant mutant bacteria: measurement and potential use of the mutant selection window. J Infect Dis 185: 561-5.

24. Zhao X, Drlica K (2001). Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies. Clin Infect Dis 33: S147-56.

25. Zhao X, Xu C, Domagala J, Drlica K (1997). DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance. Proc Natl Acad Sci USA 94: 13991-6.

26. Drlica K, Zhao X (1997). DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Revs 61: 377-92.

2.获资助课题

主持国家自然科学基金面上项目2项,参与中英抗生素耐药国际合作项目1项,

主持福建省自然科学基金面上项目1项,主持横向科研研发、合作项目3项。