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AbstractHepatitis E virus (HEV) is a significant pathogen causing acute viral hepatitis globally, posing a particular threat to pregnant women. HEV infects a range of host species, with distinct genotypes exhibiting genotype-specific tropism for different host hepatocytes. The P domain of viral capsid protein plays a central role in host cell attachment, but the molecular determinants that govern its ...
AbstractAs natural hosts of avian influenza viruses, wild birds pose an increasing threat to public health. Here, using surveillance data from wild bird infections across the United States (2022-2025), we show that HPAI-H5 transmission exhibits strong interspecific variation, seasonality, and spatial heterogeneity linked to migratory flyways. Phylogeographic analysis reveals that viral genotypes evolve ...
On January 14, a research paper titled “Variations in the Natural History of High-Risk HPV Types Following HPV-16/18 Bivalent Vaccination in Females Aged 18-45 Years” from our school was published online in the journal Nature Communications. Recently, this study was selected for the journal’s “Editors’ Highlights” in the field of microbiology and infectious diseases.Nature Communications Editors’...
SummaryHepatocellular carcinoma (HCC) is notoriously resistant to conventional chemotherapy and immunotherapy. This study presents a strategy that reprograms cisplatin into a chemoimmunotherapeutic agent by combining it with ZnNO, a fully active nanomedicine composed of sodium nitroprusside and zinc ions. Mechanistically, ZnNO enhances cisplatin chemosensitivity by depleting glutathione and releasing ...
AbstractExisting evidence regarding the impact of vaccination on the natural history of high-risk human papillomavirus (HPV) infections remains limited, understanding such effects is essential for optimizing cervical cancer screening in post-vaccination era. Using 10-year follow-up data from a phase 3 randomized trial of the Escherichia coli-produced HPV-16/18 bivalent vaccine (NCT01735006) and its ...
AbstractRespiratory syncytial virus (RSV) poses a critical threat to infants, yet vaccine and antibody development remains challenged by safety risks and antigenic variability. Here, we present a prophylactic strategy leveraging two human neutralizing antibodies, 1A2 and 1B6, which target distinct, conserved epitopes on the RSV prefusion F (pre-F) protein. Cryo–electron microscopy (cryo-EM) structural ...
AbstractThe global prevalence and disease burden of alphaherpesviruses infections, including human-infecting viruses such as HSV-1, HSV-2, and VZV, as well as animal-infecting viruses like PRV, BHV, CHV, and FHV, highlight the unmet need for more effective and universal antiviral strategies. However, there has been no significant progress in developing broad-spectrum interventions against herpesvirus....
