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AbstractImmunosuppressive tumor-associated macrophages (TAMs) create a barrier to effective antitumor immunity and promote therapeutic resistance. Reeducating TAMs to enhance their antitumor capabilities through phenotypic remodeling remains challenging. Here, we report a modular oncolytic herpesvirus platform, engineered with a PD-L1–specific chimeric receptor integrated into the viral envelope protein ...
On September 15, at the CAETS 2026 Annual Meeting in Munich, Germany, the short film The Story of China's World-First Hepatitis E Vaccine, produced by the team led by Professor Ningshao Xia of Xiamen University and recommended by the Chinese Academy of Engineering, won the sole 2026 CAETS Communication Prize. It was selected from entries recommended by CAETS member academies in 12 countries. According ...
AbstractUrban wastewater systems connect hospitals, residential communities, transport hubs, and wastewater treatment plants, creating opportunities for the dissemination of microorganisms and antibiotic resistance genes (ARGs). Here, we conduct a three-month, citywide metagenomic survey of wastewater in Xiamen, China, comprising 252 samples from seven hospital sites (n = 16), 27 residential sites ...
AbstractNucleic acid testing is widely used in tumor screening, genetic disease detection as well as prenatal diagnosis, and it especially plays a significant and irreplaceable role in detecting and controlling outbreaks or new infectious diseases. Currently, nucleic acid detection instruments measure target concentrations primarily through optical detection techniques. The characterization of the ...
SummaryBackgroundCecolin, a bivalent human papillomavirus (2vHPV) vaccine produced with Escherichia coli, has demonstrated safety and efficacy and is now widely used globally. We aimed to report the efficacy, safety, and immunogenicity profile of the nine-valent (9vHPV) vaccine, Cecolin 9.MethodsWe conducted a multicentre, double-blind, randomised, controlled, phase 3 trial at five local health centres ...
AbstractIntracavitary drug instillation is a crucial therapeutic strategy for treating bladder cancer. However, current methods are limited in efficacy due to insufficient tumour targeting and drug penetration across tissue barriers in pathophysiological conditions. Here we devise biohybrid magnetic algae microrobots with hierarchical nanoporous structure and develop an ‘algebot’-mediated, non-contact ...
SummaryBroadly neutralizing antibodies (bnAbs) are essential for the development of vaccines and therapeutics against rapidly evolving pathogens like HIV and SARS-CoV-2, yet traditional discovery methods remain technically challenging and time consuming. Here, we introduce ClonoDeep, an AI-powered platform that integrates public antibody clonotypes with a sequence-based deep learning model to directly ...
