案例信息

标题：两亲性复合多糖凝胶对痤疮创面抗炎促愈的研究

【学位类别】公共卫生

【专业领域/方向】生物材料，转化医学

【作者】许零 教授

【单位】厦门大学公共卫生学院

【关键词】两亲性、聚多糖、痤疮创面

【适用课程】生物功能材料，生物制品学，转化医学概论

【版权说明】真实性案例，仅用于教学目的

【案例摘要】

痤疮是累及毛囊皮脂腺的一种慢性炎症性皮肤病，主要多发于青春期，在青少年中发病率可达到85%，临床表现以好发于面部的粉刺、丘疹、脓疱、结节等多形性皮损为特点，青春期后相关症状会自然减轻或痊愈，但部分不及时治疗会遗留影响外观的永久性疤痕，破坏患者的个人形象从而产生社交障碍，导致患者出现明显心理健康问题，更为严重的是由于慢性炎症使得免疫力降低从而导致并发症的出现，危及生命。基于上述背景，本案例通过结合痤疮发病因素及持续炎症的治疗难点，制备具有抑菌保湿功效，能够控制持续炎症促进创面愈合减少瘢痕形成的两亲性复合多糖凝胶，希望为医疗市场治疗痤疮及其创面的抗炎促愈开拓更为广阔的道路。

Tittle: Anti inflammatory and healing effects of amphiphilic complex polysaccharide gel on acne wounds

Professional Degree Category: Biology, Medicine

Specialized fields: Biomaterials, Translational Medicine

Authors: Ling Xu

Affiliation: School of Public Health, Xiamen University

Key words: Amphiphilic , polysaccharides，acne wounds

Abstract

Acne is a chronic inflammatory skin disease involving the hair follicles and sebaceous glands. It mainly occurs in adolescence, with a incidence rate of 85% among adolescents. Its clinical manifestations are characterized by facial acne, papules, pustules, nodules and other polymorphic skin lesions. After adolescence, the related symptoms will naturally alleviate or recover, but some of them will leave permanent scars that affect the appearance and destroy the patient's personal image, resulting in social barriers, Causing obvious mental health problems for patients, and more seriously, the decrease in immune function due to chronic inflammation leads to the occurrence of complications that endanger life.

Based on the above background, this case prepares an amphiphilic polysaccharide gel that has antibacterial and moisturizing effects, can control persistent inflammation, promote wound healing, and reduce scar formation by combining the pathogenesis of acne and the treatment difficulties of persistent inflammation, hoping to open up a broader path for the medical market to treat acne and its wound anti-inflammatory and healing.

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