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Faculty

Heqing Shen

Heqing Shen Professor

Position:

Email: hqshen@iue.ac.cn; hqshen@xmu.edu.cn

Office:

Research Area:

Selected Publications

2020

  1. Jinjin Jiang, Yang Li, Shuang Liang, Baiyang Sun, Yanfeng Shi, Qing Xu, Jie Zhang, Heqing Shen, Junchao Duan, Zhiwei Sun. Combined exposure of fine particulate matter and high-fat diet aggravate the cardiac fibrosis in C57BL/6J mice. J Hazardous Materials. 2020, 391(5), 122203

  2. Jingyi Zhang, Shuang Liang, Ruihong Ning, Jinjin Jiang, Jie Zhang, Heqing Shen, Rui Chen, Junchao Duan, Zhiwei Sun. PM2.5-induced inflammation and lipidome alteration associated with the development of atherosclerosis based on a targeted lipidomic analysis. Environ Int 2020, 136, 105444

  3. Nabgha-e-Amen, Syed Ali Musstjab Akber Shah Eqani, Faiza Khuram, Ambreen Alamdar, Ayesha Tahir, Syed Tahir Abbas Shah, Arshan Nasir, Sundus Javed, Nazia Bibi, Alamdar Hussain, Hifza Rasheed, Heqing Shen. Environmental exposure pathway analysis of trace elements and autism risk in Pakistani children population. Sci Total Environ 2020, 712(10 April), 136471

  4. Meiping Tian, Benhua Zhao, Francis L. Martin, Camilo L.M. Morais, Liangpo Liu, Qingyu Huang, Jie Zhang, Heqing Shen. Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure.Environ Int 2020, 134, 105313

2019

  1. Meiping Tian, Liangpo Liu, Jie Zhang, Qingyu Huang, Heqing Shen. Positive association of low-level environmental phthalates exposure with sperm motility was mediated by DNA methylation: a pilot study. Chemosphere 2019, 220, 459-467

  2. Qingyu Huang, Liangpo Liu, Yan Wu, Xiaofei Wang, Lianzhong Luo, Bingru Nan, Jie Zhang, Meiping Tian, Heqing Shen. Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environ Int 2019, 132, 105066

  3. Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarrob, Jie Zhang, An Pan. Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men. Environ Int 2019, 129, 354–363

  4. 吴衍，张西，张洁，张雪芹，申河清. 基于液相色谱⁃质谱联用技术的妊娠期糖尿病患者脐带血代谢组学网络分析.色谱.2019，37（8），897-903；ＤＯＩ：１０．３７２４／ＳＰ．Ｊ．１１２３．２０１９．０２００６

  5. Xueyan Li, Liangpo Liu, Heng Wang, Xueqin Zhang, Tonghu Xiao, Heqing Shen*. Phthalate exposure and cumulative risk in a Chinese newborn population. Environ Sci Pollution Res 2019, https://doi.org/10.1007/s11356-019-04216-z

  6. Meiping Tian, Xi Zhang, Liangpo Liu, Francis L. Martin, Heng Wang, Jie Zhang, Qingyu Huang, Xiaofei Wang, Heqing Shen*. Phthalate side-chain structures and hydrolysis metabolism associated with steroidogenic effects in MLTC-1 Leydibg cells. Toxicology Letters 2019, 308 (15 June), 56-64.

  7. Ambreen Alamdar, Meiping Tian, Qingyu Huang, Xiaoyan Du, Jie Zhang, Liangpo Liu, Syed Tahir Abbas Shah, Heqing Shen. Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic. Ecotoxicol Environ Safety 2019, 170, 513–520

12. Meiping Tian, Qingyu Huang, Heng Wang, Francis L Martin, Liangpo Liu, Jie Zhang, Heqing Shen. Biphasic effects of perfluorooctanoic acid on steroidogenesis in mouse Leydig tumour cells. Reproductive Toxicology 2019, 83, 54-62

2018

  1. Qingyu Huang, Dayu Hu, Xiaofei Wang, Yahong Chen, Yan Wu, Lu Pan, Hongyu Li, Jie Zhang, Furong Deng, Xinbiao Guo, Heqing Shen. The modification of indoor PM2.5 exposure to chronic obstructive pulmonary disease in Chinese elderly people: A meet-in-metabolite analysis. Environ Int 121, 2018, 1243-52

  2. Yan Wu, Jie Zhang, Siyuan Peng, Xiaofei Wang, Lianzhong Luo, Liangpo Liu, Qingyu Huang, Meiping Tian, Xueqin Zhang, Heqing Shen,Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium. Environ Int121, 2018, 1227-34

  3. Zhong-Min Li, David Hernandez-Moreno, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm, Meri De Angelis; Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones, Endocrinology 2018, 159(10), 3473–81

  4. Meiping Tian, Liangpo Liu, Heng Wang, Xiaofei Wang, Francis L. Martin, Jie Zhang, Qingyu Huang, and Heqing Shen, Phthalates Induce Androgenic Effects at Exposure Levels That Can Be Environmentally Relevant in Humans. Environ Sci & Technol Letters 2018 5 (5), 232-236 DOI: 10.1021/acs.estlett.8b00138

  5. Zhong-Min Li, Florian Giesert, Daniela Vogt-Weisenhorn, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm, Meri De Angelis. Determination of thyroid hormones in placenta using isotope-dilution liquid chromatography quadrupole time-of-flight mass spectrometry. J. Chromatogra. A, 2018 ,1534, 85–92

  6. Liu, L.J., Yang, X., Wang, M.Q., Long, Y., Shen, H.Q., Nie, Y., Chen, L.X., Guo, H.Y., Jia, F., Nelson, J., Song, G.Z., Frank, A., Welles, S. and Haas, C.N. (2018) Climate Change, Air Quality and Urban Health: Evidence from Urban Air Quality Surveillance System in 161 Cities of China 2014. J Geosci Environ Protect, 6, 117-130. https://doi.org/10.4236/gep.2018.63011

  7. Eqani, Syed Ali Musstjab Akber Shah; Tanveer, Zafar Iqbal; Qiaoqiao, Chi; et al. Occurrence of selected elements (Ti, Sr, Ba, V, Ga, Sn, Tl, and Sb) in deposited dust and human hair samples: implications for human health in Pakistan. Environ Sci Pollution Res, 2018, 25, 13,12234-45

  8. Du X, Tian M, Wang X, Zhang J, Huang Q, Liu L, Shen H*. Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water.Environ Pollut. 2018, 234 (7):590-600.

  9. Muhammad Sohail, Syed Ali Musstjab Akber Shah Eqani, Joel Podgorski, Avit Kumar Bhowmik, Adeel Mahmood, Nadeem Ali, Tara Sabo-Attwood, Habib Bokhari, Heqing Shen. Persistent organic pollutant emission via dust deposition throughout Pakistan: Spatial patterns, regional cycling and their implication for human health risks. Sci Total Environ, 2018, 618(15):829-837

2017

  1. Podgorski JE, Eqani SAMAS, Khanam T, Ullah R, Shen H, Berg M, Extensive arsenic contamination in high-pH unconfined aquifers in the Indus Valley. Sci. Adv.3, e1700935 (2017).

  2. Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia, Heqing Shen*. Phthalate metabolites related to infertile biomarkers and infertility in Chinese men. Environ Pollut. 2017 Aug 12;231(Pt 1):291-300. doi: 10.1016/j.envpol.2017.08.018

  3. Heng Wang, Liangpo Liu, Syed Ali Musstjab Akber Shah Eqani, Heqing Shen*. Infant Exposure to Bisphenol A can be Quantitatively Assessed by a Simply Improved High-Performance Liquid Chromatography Tandem Mass-Spectrometry Method. Anal Sci2017, 33 (7) :777-781.

  4. Heng Wang, Liangpo Liu, Jianyue Wang, Zhendong Tong, Jianbo Yan, Tongjie Zhang, Ying Qin, Tingting Jiang, Jianwen She, Heqing Shen*. Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage: Preliminary results from a Daishan birth cohort. Sci Total Environ, 2017, 601-602(1): 1733-1742

  5. Xiaofei Wang, Shoufang Jiang, Ying Liu, Xiaoyan Du, Weibing Zhang, Jie Zhang, Heqing Shen*. Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats. Sci Total Environ, 2017, 592: 41-50.

  6. Xiaofei Wang, Liangpo Liu, Xiaoyan Du, Qingyu Huang, Meiping Tian, Weibing Zhang, Jie Zhang, Heqing Shen*. Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans. Environ Pollut, 2017, 229:168-176.

  7. WANG Xiao-Fei，JIANG Shou-Fang，ZHANG Ling-Yi，LIU Ying，DU Xiao-Yan，ZHANG Wei-Bing，ZHANG Jie，SHEN He-Qing*. Study on Reproductive Toxicity of Fine Particulate Matter by Metabonomics. Ch J Anal Chem, 2017,45(5), 633-640.

  8. Alamdar A, Xi, G., Huang, Q., Tian M., SAMAS Eqani, Shen H*. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. Toxicol Applied Pharmacol, 326 (2017) 7–14.

  9. Ali N, Eqani SAMAS, Shahzad K, Rashid MI, Ismail IMI, Shen H*, Ehtisham N, Talal A. Currently used organophosphate and brominated flame retardants in the environment of China and other developing countries (2000-2016). Environ Sci Pollution Res, 2017, 24, 18721-18741

  10. Alamdar A, Eqani SAMAS,Hanif N, Ali SM, Fasola M, Bokhari H, Katsoyiannis IA,Shen H*. Human exposure to trace metals and arsenic via consumption of fish from river Chenab, Pakistan and associated health risks. Chemosphere 168 (2017) 1004-1012