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Abstractsevereacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study explored the immunogenicity of a bivalent vaccine in rhesus macaques, containing spike (S) proteins from the prototype (Sprototype) and chimeric S protein (S1628x)...
SummaryBackgroundCecolin9, a second-generation 9-valent HPV vaccine derived from the WHO-prequalified Cecolin, has received marketing authorisation in China in May 2025. The non-inferiority of type-specific immune responses between Cecolin9 and Gardasil9 has been previously established at month 7 in Chinese women aged 18–26 years (NCT04782895). This study aimed to compare the plateau antibody levels ...
SummaryBackgroundA safe and highly efficacious Escherichia coli-produced HPV-16/18 bivalent vaccine (Cecolin®) offers a cost-effective cervical cancer prevention measure. Here, we report data on the long-term efficacy and immunopersistence up to 10 years post-vaccination.MethodsIn the Phase III clinical trial (NCT01735006), 7372 women were enrolled and randomly assigned to receive the HPV or control ...
AbstractOptical coherence tomography angiography (OCTA) is a major advancement in imaging, offering high-resolution microvascular volumetric images crucial for diagnosing and studying dermatological diseases. However, current data analysis and clinical evaluation criteria primarily rely on 2-dimensional (2D) imaging results, resulting in imprecise diagnoses due to the substantial loss of 3D curved ...
AbstractBackground & AimsPaslahepevirus balayani (bHEV), also known as hepatitis E virus (HEV), encompasses eight genotypes, five of which infect humans. Rats are natural reservoirs of Rocahepevirus ratti genotype 1 (HEV-r-1; rat HEV; rHEV), which has recently been implicated in viral hepatitis. Despite the antigenic divergence between bHEV and rHEV, studies on shared protective antibodies remain rare....
AbstractThe diffuse and infiltrative nature of high-grade gliomas poses ongoing challenges in treatment and management. Radiotherapy is an important glioma treatment, with a standard radiotherapy dose of 60 gray. However, high-dose radiotherapy is associated with radiation-induced side effects on normal tissue. Scintillator-mediated low-dose x-ray–induced photodynamic therapy using kilovoltage x-rays ...
An HIV urine self-test kit called the Human Immunodeficiency Virus (HIV) type-I urine antibody diagnostic kit (colloidal gold), co-developed by the school of public health, Xiamen University and Beijing Wantai Biological Pharmacy Enterprise, recently obtained the prequalification of medical products from the World Health Organization, known as WHO PQ.It is the world's first HIV urine self-test kit ...
![[The Lancet Regional Health-Western Pacific] Immunogenicity comparison of an Escherichia coli-produced 9-valent human papillomavirus vaccine and Gardasil9 in Chinese women aged 18–26 years: three-year follow-up data from a randomised clinical trial](/virtual_attach_file.vsb?afc=5MNrCRLzvDo7L4nQRLan7VkozG4L7QqkMR9bLmUZUmMVozN0gihFp2hmCIa0nSy8LkhkU1hVnR6fnzUanRl4Um9sM8-PM7L8L4TfLlL4LlWFnN74L7n7olWFnRNYL1baptveo4Oevsfw5DrJgDTJQty0gzL0gzLJqdpnx&oid=1944058294&e=.png)