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AbstractCombination vaccines promise to simplify immunization schedules and improve coverage, but remain technically challenging owing to antigen compatibility, immunogenic balance and formulation complexity. Here we report a modular strategy that uses a single-component nanobody binder to noncovalently attach diverse antigens to intact particles from the licensed hepatitis E vaccine. To identify a ...
AbstractBackground: Nasopharyngeal carcinoma (NPC) is notably prevalent in southern China and Southeast Asia, highlighting the need for effective screening strategies. Methods: In Zhongshan, Guangdong, a screening program involving 24,852 healthy Cantonese individuals aged 30-69 compared the Anti-BNLF2b total antibody (P85-Ab) with the EBNA1-IgA and VCA-IgA testing (two-antibody method). We examined ...
AbstractNeurotropic viruses are highly invasive in the central nervous system (CNS) and can disrupt the microcirculation, leading to neurological complications and encephalopathy. Understanding these pathophysiological alterations is crucial for uncovering the underlying mechanisms of viral infection, developing effective vaccines, and creating targeted therapies. However, studying the cerebral microcirculation ...
Abstractsevereacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study explored the immunogenicity of a bivalent vaccine in rhesus macaques, containing spike (S) proteins from the prototype (Sprototype) and chimeric S protein (S1628x)...
SummaryBackgroundCecolin9, a second-generation 9-valent HPV vaccine derived from the WHO-prequalified Cecolin, has received marketing authorisation in China in May 2025. The non-inferiority of type-specific immune responses between Cecolin9 and Gardasil9 has been previously established at month 7 in Chinese women aged 18–26 years (NCT04782895). This study aimed to compare the plateau antibody levels ...
SummaryBackgroundA safe and highly efficacious Escherichia coli-produced HPV-16/18 bivalent vaccine (Cecolin®) offers a cost-effective cervical cancer prevention measure. Here, we report data on the long-term efficacy and immunopersistence up to 10 years post-vaccination.MethodsIn the Phase III clinical trial (NCT01735006), 7372 women were enrolled and randomly assigned to receive the HPV or control ...
AbstractOptical coherence tomography angiography (OCTA) is a major advancement in imaging, offering high-resolution microvascular volumetric images crucial for diagnosing and studying dermatological diseases. However, current data analysis and clinical evaluation criteria primarily rely on 2-dimensional (2D) imaging results, resulting in imprecise diagnoses due to the substantial loss of 3D curved ...
![[Advanced Science] Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System after Intranasal Infection with Recombinant Pseudorabies Virus](/virtual_attach_file.vsb?afc=5MRlCYMlnVM7WRLQz9aUNQ2UmN4MRAqVLz9anlLsUNliMmU0gihFp2hmCIa0UShkU1y8LkyanmUanRNZMmCDMNnknR67ozrVLNlbU8Q7ozTFolVkMlLaMzfFnlrkMkbaptveo4Oevsfw5DrJgDTJQty0gzL0gzLJqdpnx&oid=1944058294&e=.png)