Education and Work Experience

2005.9-2009.7 Bachelor of Engineering, Major in Mechanical Design, Manufacturing, and Automation, Department of Mechanical and Electronic Engineering, Xiamen University

2009.8-2010.7 Mathematics Teacher (Volunteer Service), Haiyuan County Vocational High School, Ningxia

2010.9-2015.6 Ph.D. in Engineering, Major in Precision Instruments and Machinery, Department of Instrument Science and Electrical Engineering, Xiamen University

2015.7-2018.3 Postdoctoral Researcher, Major in Control Science and Engineering, Institute of Automation, Chinese Academy of Sciences.

Research Interests

Research and industrial application of medical diagnostic instruments and medical artificial intelligence. The research projects include:

(1) Development and industrialization of medical diagnostic instruments and accompanying microfluidic chips.

(2) Intelligent algorithm development for children's bone age determination.

(3) AI design of vaccine immunogens.

Product Category

Chinese Registration Certificate for Medical Device (Level III): Microfluidic-based Fully Automatic Nucleic Acid Analyzer.

Representative Publications

[1] Dongxu Zhang, Yang Yan, Yulin Huang, Bowen Liu, Qingbing Zheng, Jun Zhang and Ningshao Xia*. Unsupervised Cryo-EM Images Denoising and Clustering based on Deep Convolutional Autoencoder and K-Means++. IEEE Transactions on Medical Imaging, 2023, 42(5): 1509-1521.

[2] Yulin Huang, Jiayu Yang, Juntian Zeng, Chengxi Huang, Xianglian Gong, Shaoxian Ma, Shengxiang Ge, and Dongxu Zhang*. Design and Optimization of Ultrasound-Assisted Nucleic Acid Extraction System. IEEE Transactions on Instrumentation and Measurement. 2024, 73: 3519714.

[3] Dongxu Zhang, Runxin Gao, Shaolei Huang, Yulin Huang, Jianbin Zhang, Xiaosong Su, Shiyin Zhang, Shengxiang Ge*, Jun Zhang*, Ningshao Xia*. All-in-one microfluidic chip for 30-min quantitative point-of-care-testing of nucleic acids. Sensors and Actuators B: Chemical 2023, 390: 133939.

[4] Dongxu Zhang, Bowen Liu, Yulin Huang, Yang Yan, Shaowei Li, Jinshui He, Shuyun Zhang, Jun Zhang, Ningshao Xia*. An Automated TW3-RUS Bone Age Assessment Method with Ordinal Regression-Based Determination of Skeletal Maturity. Journal of Digital Imaging. 2023: 1-15.

[5] Dongxu Zhang, Yang Hu, Runxin Gao, Shengxiang Ge, Jun Zhang, Xianglei Zhang*, Ningshao Xia*. Numerical and experimental investigation on the performance of rapid ultrasonic-assisted nucleic acid extraction based on dispersive two-phase flow. Analytica Chimica Acta, 2023: 342176.

[6] Dongxu Zhang, Guoqiang Liu, Yongkang Lai, Xiaohui Lin, and Weihuang Cai. Numerical Simulation and Application of a Channel Heat Sink with Diamond Ribs. Water 2023, 15, 3677.

[7] JiaGeng Wu, Yang Yan, DongXu Zhang*, BoWen Liu, QingBing Zheng, XiaoLiang Xie, ShiQi Liu, ShengXiang Ge, ZengGuang Hou, NingShao Xia. Machine Learning for Structure Determination in Single-Particle Cryo-Electron Microscopy: A Systematic Review. IEEE Transactions on Neural Networks and Learning Systems. 2022, 33(2): 452-472.

[8] Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang*, Ningshao Xia*. Ultra-fast, sensitive and low-cost real-time PCR system for nucleic acid detection. Lab on a Chip 2023, 23(11): 2611-2622.

[9] An, YiQuan, ShaoLei Huang, BangChao Xi, XiangLian Gong, JunHao Ji, You Hu, YiJie Ding, DongXu Zhang*, ShengXiang Ge, Jun Zhang, NingShao Xia. Ultrafast Microfluidic PCR Thermocycler for Nucleic Acid Amplification. Micromachines. 2023, 14(3): 658.

[10] Bangchao Xi, Shaolei Huang, Yiquan An, Xianglian Gong, Jiayu Yang, Juntian Zeng, Shengxiang Ge, Dongxu Zhang*. Sophisticated and precise: design and implementation of a real-time optical detection system for ultra-fast PCR. RSC advances. 2023, 13(29): 19770-19781.

[11] Xiaohui Lin, Weihuang Cai, Shaolei Huang, Sijie Zhu, Dongxu Zhang*. Conjugate Heat Transfer Analysis and Heat Dissipation Design of Nucleic Acid Detector Instrument. Applied Sciences. 2022, 12(23): 11966.

[12] Shaolei Huang, Jiageng Wu, Haozheng Dai, Runxin Gao, Hongyu Lin, Dongxu Zhang*, Shengxiang Ge. Development of amplification system for point-of-care test of nucleic acid. Computer Methods in Biomechanics and Biomedical Engineering. 2022, 25(9): 961-970.

[13] Shaowei Li, Bowen Liu, Shulian Li, Xinyu Zhu, Yang Yan, Dongxu Zhang*. A deep learning-based computer-aided diagnosis method of X-ray images for bone age assessment. Complex & Intelligent Systems. 2021: 1-11.

[14] Xianglei Zhang, Yang Hu, Runxin Gao, Shengxiang Ge, Dongxu Zhang*. Numerical and Experimental Investigation of Liquid Residue in 90° Bend Microchannel Based on Gas–Liquid Two-Phase Flow. Fluid Dynamics. 2021, 56(Suppl 1): S34-S52.

[15] Jiasu Xu, Jin Wang, Shuizhen He, Xiaosong Su, Zecheng Zhong, Weibo Zhong, Lizhen Yan, Shaolei Huang, Jiayu Yang, Runxin Gao, Jianbin Zhang, Juntian Zeng, Dongxu Zhang, Tingdong Li, Shiyin Zhang*, Shengxiang Ge*, Jun Zhang, Ningshao Xia. Accurate nucleic acid quantification in a single sample tube without the need for calibration. Analytica Chimica Acta. 2021, 1167: 338599.

[16] Jiasu Xu, Jin Wang, Zecheng Zhong, Xiaosong Su, Kunyu Yang, Zhongfu Chen, Dongxu Zhang, Tingdong Li, Yingbin Wang, Shiyin Zhang*, Shengxiang Ge*, Jun Zhang, Ningshao Xia. Room-temperature-storable PCR mixes for SARS-CoV-2 detection. Clinical biochemistry. 2020, 84: 73-78.

[17] Wei Zhao, Dongxu Zhang*, Qichen Wang, Yanghui Chen, Juntian Zeng, Xiaosong Su, Shiyin Zhang, Shengxiang Ge. Design and Performance Research on Universal Micro Valve for Microfluidic Chip. 2020, 20(33): 13667-13672.

[18] Qichen Wang, Runxin Gao, Juntian Zeng, Dongxu Zhang*, Shengxiang Ge, Ningshao Xia. Tolerance Design of Key Features of Microvalve Based on Virtual Boundary Modal. Modular Machine Tool & Automatic Manufacturing Technique. 2022(03): 1-5.

[19] Jiayu Yang, Juntian Zeng, Bangchao Xi, Guoqiang Liu, Shaolei Huang, Dongxu Zhang*. A novel Cryo-EM images clustering method based on contrastive learning. Applied Optics. 2023, 44(04): 859-867.

[20] Yang Yan, Qingbing Zheng, Dongxu Zhang*, Shaowei Li, Shengxiang Ge, Jun Zhang, Ningshao Xia. A Clustering Algorithm for Cryo-Electron Microscopy Single Particle Images Based on Contrastive Learning. Journal of Xiamen University (Natural Science). 2022, 61(06): 1053-1061.

[21] Bangchao Xi, Jiayu Yang, Shaolei Huang, Haozheng Dai, Juntian Zeng, Dongxu Zhang*. A Straight-Axis Multi-Channel Optical Detection System for Nucleic Acid On-Site Detection. Advances in Laser and Optoelectronics Progress. 2023, 60(17): 335-343. Journal of Xiamen University (Natural Science Edition), 2025.

[22] Jingda Xiao, Yulin Huang, Bowen Liu, Wei Liu, Huibin Huang, Dongxu Zhang*, Ningshao Xia. Machine learning-based auxiliary diagnosis of active tuberculosis based on feature selection. Journal of Xiamen University (Natural Science). 2024,63(1):134-141.

[23] Guoqiang Liu, Ce Fang, Lin Xiao, Yongkang Lai, Dongxu Zhang*. Intelligent pump for sensing the operating status of microfluidic chips: design, implementation, and verification. Chinese Hydraulics & Pneumatics. 2024,48(10):150-157.

[24] Xianglian Gong, Yulin Huang, Weichun Lin, Lianwei Yang, You Hu, Shan Shao, Dongxu Zhang*. Effect of ethanol in nucleic acid extraction on quantitative real⁃time PCR. Chin J Biologicals January.

[25] Qianyao Lin, Yulin Huang, Xiaohua Wan, Dongxu Zhang*, Fa Zhang, Ningshao Xia. Multi-scale fusion focus evaluation method for digital pathology images. Journal of Xiamen University (Natural Science). 2025.

[26] Yang Yan, Jiageng Wu, Bowen Liu, Qingbing Zheng, Dongxu Zhang*, Shengxiang Ge, Jun Zhang, Ningshao Xia. A Novel Clustering Method Using Variational Autoencoder with Reliable Sample Decision and Balanced K-Means++ for Single-particle Cryo-EM Images. 2021 IEEE Data Driven Control and Learning Systems Conference (DDCLS), Suzhou, P.R. China, 2021.05.14-05.16.

[27] Yulin Huang, Jiayu Yang, Ce Fang, Lin Xiao, Yongkang Lai, Dongxu Zhang*. AFully Automated System for Rapid Nucleic Acid Extraction in Point-of-Care Testing. The 3rd international Conference on Computer, Artificial intelligence and Control Engineering (CAlCE 2024), Xi’an, P.R. China, 2024.01.26-01.28.

[28] Zhuolun Li, Jiayu Yang, Yulin Huang, Dongxu Zhang*. Real-time fluorescence signal baseline region identification during nucleic acid amplification based on BiGRU. 2024 International Joint Conference on Neural Networks (IJCNN), Qingdao, P.R. China,2024.11.01-11.03.

[29] Jinda Xiao, Yulin Huang, Jianxiong Guan, Shaoxian Ma, Dongxu Zhang*. BonCC:A Lightweight TW3-based Bone Age Assessment Coordinate Classification Model. IEEE International Joint Conference on Neural Networks (IJCNN), Yokohama, JAPAN, 2024.06.30-07.05.

[30] Chengxi Huang, Yulin Huang, Yang Hu, Jianxiong Guan, Dongxu Zhang*. Numerical studies of ultrasound-assisted magnetic beads mixing based on acoustic streaming effect. The 2024 International Conference on Biomimetic Intelligence and Robotics & Medical Robotics Forum (ICBIR+MRF 2024), Linzhi, P.R. China,2024.07.25-07.28.

Patents

[1] Dongxu Zhang, Yulin Huang, Jianbin Zhang, Runxin Gao, Jiasu Xu, Shiyin Zhang, Zuxing Weng, Liuli Wei, Shengxiang Ge, Jun Zhang, Ningshao Xia. Nucleic Acid Extraction Device and Nucleic Acid Detection System. Chinese Invention Patent, Grant Date: 2021-02-09, Patent Number: CN111187718B.

[2] Dongxu Zhang, Haozheng Dai, Shaolei Huang, Jianbin Zhang, Ya Zhang, Jin Wang, Zuxing Weng, Liuli Wei, Shiyin Zhang, Shengxiang Ge, Jun Zhang, Ningshao Xia. Fluorescence Detection Device Based on Microfluidic Chip and Microfluidic Chip Detection System. Chinese Invention Patent, Grant Date: 2020-09-29, Patent Number: CN111189814B.

[3] Dongxu Zhang, Wei Zhao, Xiaosong Su, Jiageng Wu, Shiyin Zhang, Shengxiang Ge, Jun Zhang, Ningshao Xia. Analog Detection Device and Method for Microfluidic Chips with Liquid Flow Control Valves. Chinese Invention Patent, Grant Date: 2021-10-22, Patent Number: CN111855083B.

[4] Dongxu Zhang, Zhenyu Weng, Xiaosong Su, Jiasu Xu, Shiyin Zhang, Yulin Huang, Qingshun Guo, Shengxiang Ge, Jun Zhang, Ningshao Xia. Measurement Equipment, Method, and Experimental Setup for Energy Transfer Efficiency of Microfluidic Chips. Chinese Invention Patent, Grant Date: 2021-07-02, Patent Number: CN111122707B.

[5] Dongxu Zhang, Shengxiang Ge, Shiyin Zhang, Xiaosong Su, Xiaoping Min, Zhenyu Weng, Qingshun Guo, Jun Zhang, Ningshao Xia. Connector, Its Combination with Reagent Module and Microfluidic Chip. Chinese Invention Patent, Grant Date: 2021-02-23, Patent Number: CN110856822B.

[6] Dongxu Zhang, Runxin Gao, Juntian Zeng, Shaolei Huang, Chengxi Huang, Guoqiang Liu, Xinquan Zhong, Shengxiang Ge, Jun Zhang, Ningshao Xia. Microfluidic chip and microfluidic chip detection system. Chinese Utility Model Patent, Grant Date: 2025-02-14, Patent Number: CN116135313B.

[7] Dongxu Zhang, Runxin Gao, Xinquan Zhong, Manshu Du, Zhibo Kong, Jianbin Zhang, Juntian Zeng, Shengxiang Ge, Jun Zhang, Ningshao Xia. Microfluidic chip components. Chinese Utility Model Patent, Grant Date: 2024-09-24, Patent Number: CN115212932B.

[8] Dongxu Zhang, Jiayu Yang, Guoqiang Liu, Junhao Ji, Jianbin Zhang, Zhibo Kong, Shengxiang Ge, Jun Zhang, Ningshao Xia. Force application components and microfluidic chip components. Chinese Utility Model Patent, Grant Date: 2024-08-16, Patent Number: CN115364914B.

[9] Dongxu Zhang, Shaolei Huang, Yunhui Lin, Zhibo Kong, Yanghui Chen, Jianbin Zhang, Shengxiang Ge, Jun Zhang, Ningshao Xia. Temperature control device and microfluidic detection system. Chinese Utility Model Patent, Grant Date: 2024-08-9, Patent Number: CN115318348B.

[10] Dongxu Zhang, Yulin Huang, Juntian Zeng, Lin Xiao, Jianxiong Guan, Shaoxian Ma, Shengxiang Ge, Jun Zhang, Ningshao Xia. Measurement Device for Scoliosis. Chinese Utility Model Patent, Grant Date: 2023-02-03, Patent Number: CN218419852U.

[11] Shengxiang Ge, Dongxu Zhang, Jianbin Zhang, Jiageng Wu, Shaolei Huang, Shiyin Zhang, Xiaoping Min, Zuxing Weng, Liuli Wei, Jun Zhang, Ningshao Xia. Microfluidic Chip Manipulation Equipment, Microfluidic System and Microfluidic Chip. Chinese Invention Patent, Grant Date: 2021-01-05, Patent Number: CN111135892B.

[12] Shengxiang Ge, Qichen Wang, Dongxu Zhang, Jianbin Zhang, Juntian Zeng, Yanghui Chen, Zuxing Weng, Liuli Wei, Shiyin Zhang, Jun Zhang, Ningshao Xia. Puncturing Device for Microfluidic Chips and Microfluidic Chip Detection System. Patent Grant Date: 2020-11-27, Patent Number: ZL202010108194.2, China.

[13] Shengxiang Ge, Xiaosong Su, Shiyin Zhang, Dongxu Zhang, Xiaoping Min, Jin Wang, Wendi Chen, Qingshun Guo, Jun Zhang, Ningshao Xia. Microfluidic Chip and Its Operating Method. Patent Grant Date: 2021-1-5, China, ZL201810957492.1.

[14] Xiaoping Min, Shengxiang Ge, Shiyin Zhang, Dongxu Zhang, Da Fu, Jianzhong Zhang, Zhenyu Weng, Wendí Chen, Zuxing Weng, Liuli Wei, Jun Zhang, Ningshao Xia. Microfluidic Chip, Microfluidic System and Operating Method. Patent Grant Date: 2021-3-5, China, ZL201810953073.0.

[15] Shengxiang Ge, Xiaosong Su, Shiyin Zhang, Dongxu Zhang, Xiaoping Min, Juntian Zeng, Qingshun Guo, Jun Zhang, Ningshao Xia. Reagent Storage Module, its Combination with a Connector and Microfluidic Chip. Patent Grant Date: 2020-11-24, China, ZL201810957453.1.

[16] Shengxiang Ge, Shiyin Zhang, Xiaosong Su, Dongxu Zhang, Xiaoping Min, Jianzhong Zhang, Ya Zhang, Qingshun Guo, Jun Zhang, Ningshao Xia. Reaction Chamber Module and Microfluidic Chip. Patent Grant Date: 2020-11-3, China, ZL201810957452.7.

[17] Xiaoping Min, Shengxiang Ge, Xiaosong Su, Shiyin Zhang, Dongxu Zhang, Wei Zhao, Qingshun Guo, Jun Zhang, Ningshao Xia. Liquid Flow Guide Valve for Microfluidic Chips and Microfluidic Chip. Patent Grant Date: 2020-10-16, China, ZL201810957451.2.

[18] Hao Lin, Shengda Liu, Bin Wang, Peijun Dai, Yibin Liu, Qingba Jiang, Dongxu Zhang, Shaolei Huang, Xinquan Zhong, Jianbin Zhang, Junhao Ji. Fully Automatic Nucleic Acid Analyzer Microfluidic Chip. Chinese Utility Model Patent, Grant Date: 2023-02-28, Patent Number: CN218539694U (Patentee: Xiamen UMIC Medical Instruments Co., Ltd.).

[19] Shengda Liu, Hao Lin, Bin Wang, Xingxing Mao, Peijun Dai, Yibin Liu, Guolin Li, Guoqiang Liu, Junhao Ji, Yanghui Chen, Dongxu Zhang. Processing Mechanism for Microfluidic Chips. Chinese Utility Model Patent, Grant Date: 2022-05-10, Patent Number: CN216458924U (Patentee: Xiamen UMIC Medical Instruments Co., Ltd.).

Software Copyrights

[1] Dongxu Zhang, Bowen Liu, Yulin Huang, Jun Zhang, Ningshao Xia. Intelligent System for Children's Bone Age Assessment V1.0. Registered and Authorized, Registration Number: 2022SR0912837.

[2] Dongxu Zhang, Jiageng Wu, Ningshao Xia, et al. Human-Machine Interaction System for On-site Rapid Nucleic Acid Testing Instrument V1.0. Registered and Authorized, Registration Number: 2021SR0070864.

[3] Shoujie Huang, Dongxu Zhang, et al. Clinical Research Identity Information Management System V1.0. Registered and Authorized, Registration Number: 2021SR0070863.

Research Projects

[1] National Natural Science Foundation of China - General Program, 62472365, Intelligent immunogenic design of broad-spectrum vaccines for highly variable pathogens, 2025-01 to 2029-12, Funding: 500,000 RMB, In Progress, Principal Investigator.

[2] National Natural Science Foundation of China - Youth Program, 62003284, The Action Mechanism and Control Method of Ultrasonic-assisted Nucleic Acid Extraction, 2021-01 to 2023-12, Funding: 240,000 RMB, Completed, Principal Investigator.

[3] Key Research and Development and Conversion Plan of Inner Mongolia Autonomous Region, 2023YFDZ0060, Development of a New Bone Age Intelligent Assessment Device for Children and Adolescents, 2023-01 to 2025-12, Funding: 350,000 RMB, In Progress, Coordinating Investigator.

[4] Xiamen Natural Science Foundation General Project, 3502Z202473003, Artificial Intelligence-based Broad-spectrum Influenza Vaccine Virus Vector Immunogen Design, 2024-07 to 2027-06, 80,000 RMB, In progress, Principal Investigator.

[5] Xiamen Huli District Maternal and Child Care Hospital – Horizontal Project, 20223160A0463, Correlation Study Between Vitamin A/E Levels and Respiratory Infections among Children, 2022-07 to 2027-07, Funding: 89,600 RMB, In Progress, Principal Investigator.

[6] Inner Mongolia Autonomous Region Science and Technology Plan Project, 2025YFDZ0108, Research and Application of Adaptive Resolution Imaging and Intelligent Interpretation Instruments for Digital Pathology. 2025-01 to 2027-12, 1,000,000 RMB, In progress, Coordinating Investigator.

[7] Xiamen Science and Technology Plan Project, 35022022YJ05, Automatic Nucleic Acid Analysis System Microfluidic Chip-based for Novel Coronavirus, 2022-10 to 2023-10, Funding: 100,000 RMB, Completed, Principal Investigator.

[8] Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. – Horizontal Project, 20213160A0670, Development of Three Biochemical Test Kits, 2021-01 to 2022-12, Funding: 1,600,000 RMB, Completed, Principal Investigator.

[9] China Postdoctoral Science Foundation - General Program, 2016M591285, Research on Complex Motion Control and Online Processing Technology for Optical Balloon Polishing, 2016-03 to 2017-08, Funding: 50,000 RMB, Completed, Principal Investigator.

[10] Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. - Horizontal Project, XDHT2020668A, Purification and Identification of Biological Active Materials for Major Infectious Diseases Diagnostic Reagents, 2021-01 to 2022-12, Funding: 8,000,000 RMB, Completed, Contributor.

[11] Guide Project of Science and Technology of Fujian Province, 2021Y0093, Development of a POCT System of Nucleic Acid for Novel Coronavirus, 2021-08 to 2022-08, Funding: 400,000 RMB, Completed, Contributor.

[12] Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. - Horizontal Project, 20223160A0944, Research on Pharmacodynamics Evaluation and Protective Mechanism for Rotavirus Vaccine, 2022-01 to 2023-12, Funding: 4,000,000 RMB, Completed, Contributor.