Dr. Huayun Shi obtained her PhD degree with a Chancellor’s International Scholarship in the Department of Chemistry at University of Warwick (UK) under supervision of Prof. Peter Sadler (Fellow of Royal Society) in 2019. Her research focuses on the development of novel photoactive platinum complexes with azido ligands in cancer therapy and their mechanisms of action. She has published more than 20 SCI papers and has been awarded research grants with a total value more than £360,000 (¥3.3 million).
Education Background and Working Experience
2024.12-now,Xiamen University,Assistant Professor
2020.01-2024.08,University of Warwick,Research Fellow (PI: Prof. Peter J Sadler, FRS)
2015.10-2019.11,University of Warwick,PhD (Supervisor: Prof. Peter J Sadler, FRS; Chancellor's International Scholarship)
2011.09-2015.06,Sun Yat-sen University,Bachelor
Research Interest
Photoactivated chemotherapeutic Pt(IV) prodrugs
X-ray induced phototherapy
Photoactive nanotheranostics
Representative Publication
1. H. Shi, R. Marchi, P. J. Sadler,* Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics, Angew. Chem. Int. Ed., 2025, 64, e202403335.
2. H. Shi,* O. W. L. Carter, F. Ponte, C. Imberti, M. A. Gomez-Gonzalez, F. Cacho-Nerin, P. D Quinn, J. E. Parker, E. Sicilia,* H. Huang,* P. J. Sadler,* A photodynamic and photochemotherapeutic platinum-iridium charge-transfer conjugate for anticancer therapy, Angew. Chem. Int. Ed., 2024, 63, e202400476.
3. H. Shi, F. Ponte, J. S Grewal, G. J Clarkson, C. Imberti, I. Hands-Portman, R. Dallmann, E. Sicilia,* P. J. Sadler,* Tuning the photoactivated anticancer activity of Pt(IV) compounds via distant ferrocene conjugation, Chem. Sci., 2024, 15, 4121–4134.
4. H. Shi,* G. J. Clarkson, P. J. Sadler,* Tuning the phototherapeutic activity of Pt(IV) complexes for bladder cancer via modification of trans N-heterocyclic ligands, Inorg. Chem. Front., 2024, 11, 7898–7909.
5. H. Shi, C. Imberti, G. J. Clarkson, P. J. Sadler,* Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes, Inorg. Chem. Front., 2020, 7, 3533–3540.
