研究领域：生物医学工程、分子影像、核医学、纳米医学
关键词：免疫细胞、氧化应激、细胞损伤和修复、移植、铁死亡、磁共振成像、分子探针、纳米医学
个人概况：研究兴趣方向包括（1）免疫细胞功能活性的可视化、分子调控及诊疗研究；（2）细胞、组织、器官移植的新策略研究；（3）铁死亡分子影像及疾病诊疗调控研究；（4）核素类分子探针/药物的开发及临床转化。主持国家自然科学基金以及企业委托开发的横向项目多项，负责了用于IND申报核素类药物的药学和非临床部分研究，多项参与的新药申报项目获得临床试验批件，正在开展I-III期临床。担任《Chemical & Biomedical Imaging》美国化学会（ACS）杂志青年顾问委员（ECAB）、《iRADIOLOGY》杂志青年编委、《Chinese Chemical Letters》杂志高级编委、中国生物材料学会纳米生物材料分会委员、中国抗癌协会医工整合专业委员会委员、中国生物物理学会分子影像分会委员、福建省预防医学会首届生育力保护专委会委员等职务。
图1：免疫细胞功能活性的可视化、分子调控及诊疗研究
图2：铁死亡分子影像探针设计及相关疾病诊疗调控研究
代表性论文（*通讯作者，†共同一作）
1. Dansylated Amino Acid–Modified Long-Acting PSMA Derivatives 68Ga/177Lu-LNC1011 as Prostate Cancer Theranostics. Yang, H.; Wang, J.; Wen, X.; Guo, H.; Jakobsson, V.; Zhao, T.; Zeng, F.; Shen, H.; Zhang, H.; Liu, X.; Qin, Y.; Li, X.; Xiong, H.; Zhou, Z.*; Zhang, J.*; Chen, X.* Journal of Nuclear Medicine 2025, 66 (5), 739-747.
2. Inhibiting Neutrophil Extracellular Trap Formation through Iron Regulation for Enhanced Cancer Immunotherapy. Ye, J.; Qin, Y.; Liu, H.; Xiong, H.; Zhang, H.; Shen, H.; Zeng, F.; Shi, C.; Zhou, Z.* ACS Nano 2025, 19, 9167-9181.
3. Preclinical and First-in-Human Study of a Compact Radionuclide Labeled Self-Assembly Nanomedicine for Chemo-Radio-Theranostics of Cancer. Xiong, H.; Wang, R.; Zhang, H.; Zhang, Q.; Qin, Y.; Du, C.; Zhang, X.; Ye, J.; Shi, C.; Shen, H.; Zhu, Z.*; Zhou, Z.*; Chen, X.*; Zhang, J.*; ACS Nano 2025, 19, 3953-3965.
4. Leukemia Cell Hitchhiking Hypoxia Responsive Nanogel for Improved Immunotherapy of Acute Myeloid Leukemia. Chen, H.; Wang, D.; Yao, Y.; Xiao, Y.; Zhao, Z.; Zhang, Z.; Liu, S.; Wang, X.; Yang, S.; Huang, P.; Zhou, Z.*; Zhu, X.*; Guo, W.* Advanced Functional Materials 2024, 34(48), 2411439.
5. Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments. Liu, X.; Wang, M.; Jiang, Y.; Zhang, X.; Shi, C.; Zeng, F.; Qin, Y.; Ye, J.; Hu, J.; Zhou, Z.* ACS Nano 2023, 17, 24854-24866.
6. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Shi, C.; Zhang, Q.; Yao, Y.; Zeng, F.; Du, C.; Nijiati, S.; Wen, X.; Zhang, X.; Yang, H.; Chen, H.; Guo, Z.; Zhang, X.; Gao, J.; Guo, W.*; Chen, X.*; Zhou, Z.* Nature Nanotechnology 2023, 18, 86-97.
7. Ferroptosis MRI for Early Detection of Anticancer Drug-Induced Acute Cardiac/KidneyInjuries. Zeng, F.; Nijiati, S.; Liu, Y.; Yang, Q.; Liu, X.; Zhang, Q.; Chen, S.; Su, A.; Xiong, H.; Shi, C.; Cai, C.; Lin, Z.; Chen, X.*; Zhou, Z.* Science Advances 2023, 9, eadd8539.
8. Zhou, Z.*; Du, C.; Zhang, Q.; Yu, G.; Zhang, F.*; Chen, X.* Exquisite Vesicular Nanomedicine by Paclitaxel Mediated Co-assembly with Camptothecin Prodrug. Angew. Chem. Int. Ed. 2021, 60, 21033-21039.
