个人简介

施华韵博士于2019年毕业于英国华威大学化学系，师从英国皇家学会院士Peter J Sadler教授，长期从事含叠氮配体的光活化铂类抗肿瘤药物的研发，取得了一系列创新性成果并致力于其临床转化的推进。至今发表SCI学术论文20余篇，引用次数 > 1200次。在英国工作期间，承担经费总额度超36万英镑（折合人民币330万元）。担任Inorg. Chem. Front.等国际学术期刊审稿人。

教育背景与工作经历

2024.12-现在，厦门大学，助理教授

2020.01-2024.08，华威大学，博士后 (导师：Prof. Peter J Sadler, FRS)

2015.10-2019.11，华威大学，博士 (导师：Prof. Peter J Sadler, FRS；奖学金：Chancellor's International Scholarship)

2011.09-2015.06，中山大学，学士

研究兴趣

Photoactivated chemotherapeutic Pt(IV) prodrugs

X-ray induced phototherapy

Photoactive nanotheranostics

主要代表性论著

1. H. Shi, R. Marchi, P. J. Sadler,^* Advances in the Design of Photoactivatable Metallodrugs: Excited State Metallomics, Angew. Chem. Int. Ed., 2025, 64, e202403335.

2. H. Shi,^* O. W. L. Carter, F. Ponte, C. Imberti, M. A. Gomez-Gonzalez, F. Cacho-Nerin, P. D Quinn, J. E. Parker, E. Sicilia,^* H. Huang,^* P. J. Sadler,^* A photodynamic and photochemotherapeutic platinum-iridium charge-transfer conjugate for anticancer therapy, Angew. Chem. Int. Ed., 2024, 63, e202400476.

3. H. Shi, F. Ponte, J. S Grewal, G. J Clarkson, C. Imberti, I. Hands-Portman, R. Dallmann, E. Sicilia,^* P. J. Sadler,^* Tuning the photoactivated anticancer activity of Pt(IV) compounds via distant ferrocene conjugation, Chem. Sci., 2024, 15, 4121–4134.

4. H. Shi,^* G. J. Clarkson, P. J. Sadler,^* Tuning the phototherapeutic activity of Pt(IV) complexes for bladder cancer via modification of trans N-heterocyclic ligands, Inorg. Chem. Front., 2024, 11, 7898–7909.

5. H. Shi, C. Imberti, G. J. Clarkson, P. J. Sadler,^* Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes, Inorg. Chem. Front., 2020, 7, 3533–3540.