郑清炳，博士，男，厦门大学公共卫生学院，高级工程师，硕士生导师。翔安创新实验室（福建省实验室）研究员；冷冻电镜平台技术主管；福建省杰青、青年拔尖人才、高层次人才。
个人简介
聚焦于人类重要病毒的广谱免疫靶点和机制研究，为新型疫苗研发提供创新性靶标，推动多个创新疫苗的产业化进程，产生了多个具有临床转化潜力的研究成果。共发表SCI论文80余篇，其中以通讯/第一作者(含共同)在Cell Host Microbe (2022a, 2022b, 2021, 2020), Sci Transl Med (2026), Nat Microbiol (2024, 2020, 2019), Nat Methods (2025), Nat Commun (2026, 2025, 2024, 2023, 2022a, 2022b, 2021, 2017), Sci Adv (2024, 2018)及PNAS (2025, 2022a, 2022b)等高水平期刊发表30余篇论文，被Cell Host Microbe、Nat Meth等期刊专文评述，并获评Cell出版社2020年度论文；获授权专利9项，其中国际授权3项；主持国家自然科学基金重大研究计划、面上、青年等项目10余项。
工作经历
(1) 2024-11 至 今, 翔安创新实验室, 研究员
(2) 2019-08 至 今, 厦门大学, 公共卫生学院, 高级工程师
(3) 2013-09 至 2019-07, 厦门大学, 公共卫生学院, 工程师
(4) 2016-10 至 2016-12, 加州大学洛杉矶分校, 访问学者
教育经历
(1) 2007-09 至 2013-06, 厦门大学, 细胞生物学, 博士，导师：张军教授，夏宁邵教授
(2) 2003-09 至 2007-06, 厦门大学, 生物技术, 学士
主持课题
(1) 国家自然科学基金国际重大研究计划(培育项目)，92581119，病毒mRNA稳定性调控机制及广谱抗病毒靶点研究，2026-01-01至2028-12-31，70万元，在研，主持
(2) 国家自然科学基金国际(地区)合作与交流项目，W2511070，冷冻电镜柔性多构象高精度三维重构技术，2026-01-01至2030-12-31，231万元，在研，子课题负责人
(3) 国家自然科学基金面上项目, 32170942，肠道病毒D68与受体ICAM-5相互作用的结构基础及靶向受体结合域广谱中和抗体的作用机制，2022-01-01 至 2025-12-31，58万元，在研，主持
(4) 国家自然科学基金青年项目，8140166，柯萨奇病毒A16实心/空心颗粒抗原性差异的结构基础，2015-01-01至2017-12-31,23万元，已结题，主持
(5) 福建省自然科学基金杰青青年项目，2025J010010，病毒隐匿性广谱免疫靶点的机制及应用研究，2025-09至2028-08，40万元，在研，主持
(6) 厦门市科技计划，重组大肠杆菌高密度发酵过程优化，2019-01-10至2020-12-31，75万，已结题，主持
代表性论文（*通讯或共同通讯，#一作或共同第一）
(1) Sun Y#, Liu L#, Jiang Z#, Wang Y#, Zhao J#, Qiang H#, Shi Y, Lai Q, Chen L, Zhang Q, Li J, Zhuo Z, Jiang Y, Fu Y, Zhang X, Zhang M, Lei S, Lin X, Lin M, Wang Y, Yu H, Li S, Luo W, Zhang J, Wang S*, Xia N*, Zheng Q*, Zheng Z*. An antibody cocktail targeting conserved, nonoverlapping epitopes prevents viral escape and confers protection against RSV in vivo. Sci Transl Med. 2026 Jan 14;18(832):eady2450.
(2) Zhen X#, Li Y#, Liu Z#, Huang Y#, Wang X#, Xu S, Jiang Y, Li F, Su J, Lai Q, Li S*, Xia N*, Zheng Q*, Ouyang S*. Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate. Mol Cell. 2026 Feb 3:S1097-2765(26)00068-7.
(3) Zhang W#, Jiang Y#, Li Y#, Zhen X#, Xu S, Xia NS, Li S, Wang X*, Zheng Q*, Ouyang S*. Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system. Nat Commun. 2026 Jan 6;17(1):115.
(4) Wang G#, Li Y#, Wu C#, Chen T#, Gui M#, Zeng Y#, Sun H#, Chen K, Xi X, Yang Y, Jiang Y, Jiang Y, Liu L, Yang C, Xin J, Liu C, Li Y, Huo N, Huang Y, Lin L, Yu H, Huang C, Yuan Q, Li S, Tian K*, Zheng Q*, Xia N*, Chen Y*. A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion. Nat Commun. 2025 Dec 16;16(1):11144.
(5) Sun H#, Jiang Y#, Lan M#, Zhou M#, Yi G, Shen J, Deng T, Liu L, Huang Y, Li Y, Su J, Lin Y, Chen Z, Zhou L, Li T, Yu H, Cheng T, Zhang Y, Yuan L, Li S*, Gu Y*, Zhang P, Xia N*, Zheng Q*. Engineering a multivalent antibody nanoparticle to overcome SARS-CoV-2 Omicron immune evasion. PLoS Pathog. 2025 Dec 8;21(12):e1013744.
(6) Chen Z#, Liu L#, Situ J#, Li G#, Guo S#, Lai Q, Wu S, Jiang Y, Fan J, Tang Z, Li Y, Wen G, Wang S, Ying D, Liang Y, Siu-Fung Ho S, Ma X, Yiu-Hung Tsoi J, Shun EH, Chew NF, Ma W, Mao W, Li T, Chen Z, Fang M, Wang Y, Yu H, Zhang F, Zhang AJ, Li S, Xia N*, Sridhar S*, Zheng Q*, Zheng Z*. Antibodies elicited by hepatitis E vaccination in humans confer cross-genus protection against rat hepatitis E virus. J Hepatol. 2025 Nov;83(5):1046-1056.
(7) Wang S#, Sun H#, Wang Y#, Wang Z#, Yuan L, Guo H, Gao J, Lan M, Wu Y, Shang H, Chen X, Chen Z, Hu J, Tang Z, Wen G, Ying D, Liu C, Jiang Y, Su J, Lin M, Wu T, Li S, Zhang T, Zhang J, Guan Y, Xia N,* Yuan Q*, Zheng Q*, Zhang Y*, Zheng Z*. Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants. PNAS. 2025 Sep 2;122(35):e2503254122.
(8) Xiong H#, Chang Q#, Ding J#, Wang S#, Zhang W#, Li Y#, Wu Y, Lin P, Yang C, Liu M, Fang G, Yang Y, Xie J, Qi D, Jiang T, Fu W, Hu F, Chen Y, Yue R, Li Y, Cui Y, Li M, Fan S, Yang Y, Xu Y, Li D, Zhang F, Zhao H, Wu C*, Zheng Q*, Piatkevich KD*, Fu Z*. A highly stable monomeric red fluorescent protein for advanced microscopy. Nat Methods. 2025 Jun;22(6):1288-1298. （封面论文，同期评述：https://doi.org/10.1038/s41592-025-02675-6）
(9) Huang Y#, Song F#, Zeng Y#, Sun H#, Sheng R#, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H, Li S*, Li T*, Zheng Q*, Ge S*, Zhang J, Xia N*. A single residue switch mediates the broad neutralization of Rotaviruses. Nat Commun. 2025 Jan 20;16(1):838.
(10) Guo C#, Sun H#, Du Y, Dai X, Pang Y, Han Z, Xiong X, Li S, Zhang J*, Zheng Q*, Gui X*. Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization. J Exp Clin Cancer Res. 2025 Jan 2;44(1):1.
(11) Sun Y#, Liu L#, Qiang H#, Sun H#, Jiang Y#, Ren L, Jiang Z, Lei S, Chen L, Wang Y, Lin X, Wang G, Huang Y, Fu Y, Shi Y, Chen X, Yu H, Li S, Luo W, Liu E*, Zheng Q*, Zheng Z*, Xia N*. A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein. Nat Commun. 2024 Nov 21;15(1):10085.
(12) Zhu R#, Wu Y#, Huang Y#, Jiang Y#, Jiang Y#, Zhang D#, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S*, Zheng Q*, Xu L*, Xia N*, Cheng T*. Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2. Nat Microbiol. 2024 Nov;9(11):2939-2953.
(13) Zhang H#, Li Y#, Li L, Chen L, Zhu C, Sun L, Dong P, Jing D, Yang J, Fu L, Xiao F, Xia N, Li S*, Zheng Q*, Wu Y*. Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system. Sci Adv. 2024 Aug 2;10(31):eadn5691.
(14) Sun H#, Deng T#, Zhang Y#, Lin Y#, Jiang Y#, Jiang Y#, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S*, Zheng Q*, Gu Y*, Xia N*. Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell. 2024 Feb 1;15(2):121-134.
(15) Hong J#, Zhong L#, Liu L#, Wu Q#, Zhang W#, Chen K#, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M*, Zheng Q*, Chen Y*, Zhang X*, Xia N*. Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med. 2023 Nov 21;4(11):101296.
(16) Sun H#, Wang Y#, Chen X#, Jiang Y#, Wang S, Huang Y, Liu L, Li Y, Lan M, Guo H, Yuan Q, Zhang Y, Li T, Yu H, Gu Y, Zhang J, Li S*, Zheng Z*, Zheng Q*, Xia N. Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant. J Virol. 2023 Nov 30;97(11):e0113723.
(17) Huang Y#, Sun H#, Wei S#, Cai L, Liu L, Jiang Y, Xin J, Chen Z, Que Y, Kong Z, Li T, Yu H, Zhang J, Gu Y, Zheng Q*, Li S*, Zhang R*, Xia N*. Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun. 2023 Jun 17;14(1):3609.
(18) Wu Y#, Wang S#, Zhang Y#, Yuan L#, Zheng Q#, Wei M#, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T*, Zhang J*, Cao H*, Zhu H*, Yuan Q*, Guan Y*, Xia N*. Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine. Cell Host Microbe. 2022 Dec 14;30(12):1732-1744.e7.
(19) Zheng Q#, Zhu R#, Yin Z#, Xu L#, Sun H#, Yu H, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y*, Cheng T*, Li S*, Xia N*. Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe. 2022 Sep 14;30(9):1279-1294.e6. （同期评述：https://doi.org/10.1016/j.chom.2022.08.010）
(20) Li T#, Chen J#, Zheng Q#, Xue W#, Zhang L, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y*, Chen Y*, Li S*, Xia N*. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun. 2022 Sep 2;13(1):5182.
(21) Xiong H#, Sun H#, Wang S#, Yuan L#, Liu L#, Zhu Y#, Zhang J, Huang Y, Qi R, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan S, Yue M, Wu Y, Wei M, Wang Y, Li T, Wang Y, Zheng Z, Yu H, Cheng T, Li S, Yuan Q*, Zhang J*, Guan Y*, Zheng Q*, Zhang T*, Xia N*. The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2. PNAS. 2022 Aug 23;119(34):e2204256119.
(22) Zhang X#*, Hong J#, Zhong L#, Wu Q, # Zhang S, Zhu Q, Chen H, Wei D, Li R, Zhang W, Zhang X, Wang G, Zhou X, Chen J, Kang Y, Zha Z, Duan X, Huang Y, Sun C, Kong X, Zhou Y, Chen Y, Ye X, Feng Q, Li S, Xiang T, Gao S, Zeng MS, Zheng Q*, Chen Y*, Zeng YX*, Xia N*, Xu M*. Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion. PNAS. 2022 Aug 9;119(32):e2202371119.
(23) Wang S#, Sun H#, Zhang Y#, Yuan L#, Wang Y#, Zhang T#, Wang S, Zhang J, Yu H, Xiong H, Tang Z, Liu L, Huang Y, Chen X, Li T, Ying D, Liu C, Chen Z, Yuan Q, Zhang J, Cheng T, Li S, Guan Y*, Zheng Q*, Zheng Z*, Xia N*. Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep. 2022 May 24;39(8):110862.
(24) Wang G#, Zha Z#, Huang P#, Sun H#, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q*, Chen Y*, Li S*, Xia N*. Structures of pseudorabies virus capsids. Nat Commun. 2022 Mar 22;13(1):1533.
(25) Ju B#, Zheng Q#, Guo H#, Fan Q#, Li T#, Song S#, Sun H, Shen S, Zhou X, Xue W, Cui L, Zhou B, Li S*, Xia N*, Zhang Z*. Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209. Cell Res. 2022 May;32(5):491-494.
(26) Li T#, Xue W#, Zheng Q#, Song S#, Yang C#, Xiong H#, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH*, Zhang Z*, Li S*, Gu Y*, Xia N*. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun. 2021 Sep 27;12(1):5652.
(27) Xu L#, Zheng Q#, Zhu R#, Yin Z#, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH*, Li S*, Cheng T*, Xia N*. Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe. 2021 Mar 10;29(3):448-462.e5.
(28) Wang W#, Zheng Q#, Pan D#, Yu H#, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S*, Zhu H*, Zhou ZH*, Cheng T*, Xia N*. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nat Microbiol. 2020 Dec;5(12):1542-1552.
(29) He M#, Xu L#, Zheng Q#, Zhu R#, Yin Z#, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH*, Cheng T*, Li S*, Xia N*. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe. 2020 Feb 12;27(2):249-261.e5. （Cell出版社2020中国年度论文）
(30) Zheng Q#, Jiang J#, He M#, Zheng Z#, Yu H#, Li T, Xue W, Tang Z, Ying D, Li Z, Song S, Liu X, Wang K, Zhang Z, Wang D, Wang Y, Yan X, Zhao Q, Zhang J, Gu Y*, Li S*, Xia N*. Viral neutralization by antibody-imposed physical disruption. PNAS. 2019 Dec 26;116(52):26933-26940.
(31) Zheng Q#, Zhu R#, Xu L#, He M#, Yan X#, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH*, Graham BS*, Cheng T*, Li S*, Xia N*. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nat Microbiol. 2019 Jan;4(1):124-133.
(32) Zhu R#, Xu L#, Zheng Q#, Cui Y#, Li S#, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X*, Hong Zhou Z*, Cheng T*, Xia N*. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv. 2018 Sep 19;4(9):eaat7459.
(33) Xu L#, Zheng Q#, Li S#, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T*, Zhou ZH*, Yan X*, Xia N*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nat Commun. 2017 Sep 11;8(1):505. （F1000推荐论文）
授权专利
(1) 陈毅歆，郑清炳，李睿，沈晨光，柯少君，罗文新，陈鸿霖，夏宁邵；识别流感病毒血凝素蛋白HA1结构域的广谱单克隆抗体，2018-11-30，中国，ZL201410129263.2
(2) Yixin Chen, Qingbing Zheng, Rui Li, Chenguang Shen, Shaojun Ke, Wenxin Luo, Honglin Chen, Ningshao Xia; Broad-Spectrum Monoclonal Antibody Recognizing HA1 Domain of Hemagglutimin of Influenza Virus, 2017-5-16, 美国, US9650434B2
(3) Yixin Chen, Qingbing Zheng, Rui Li, Chenguang Shen, Shaojun Ke, Wenxin Luo, Honglin Chen, Ningshao Xia; Broad-Spectrum Monoclonal Antibody Recognizing HA1 Domain of Hemagglutimin of Influenza Virus, 2020-6-5, 欧洲, EP2982691B1
(4) Yixin Chen, Qingbing Zheng, Rui Li, Chenguang Shen, Shaojun Ke, Wenxin Luo, Honglin Chen, Ningshao Xia; 识别流感病毒血凝素蛋白HA1结构域的广谱单克隆抗体, 2020-6-5, 中国香港, 1214834B
(5) 李少伟，王大宁，李智海，范飞，郑清炳，夏宁邵；一种人乳头瘤病毒6型L1蛋白的突变体，2019- 11-5，中国，ZL201611095710.2
(6) 陈毅歆，桂勋，吴兴容，黄德党，郑清炳，夏宁邵；甲型流感病毒衣壳蛋白的抗原表位及其用途，2018-2-9，中国，ZL201110122466.5
(7) 顾颖，郑清炳，李婷婷，俞海，薛文辉，陈婷婷，李少伟，夏宁邵；具有融合前早期构象的SARS- CoV-2 S三聚体蛋白及其应用，2024-02-06，中国，CN202110268273.4
(8) 郑子峥，孙永鹏，郑清炳，雷思雨，强宏生，陈莉，夏宁邵；识别RSV pre-F蛋白的抗体以及应用，2022年08月15日，中国，ZL202210976507.5
学术荣誉及学术兼职
1. 学术荣誉
(1) 2025，福建省
杰青(2) 2023，全国高校黄大年式教师团队
(3) 2022，厦门市高层次人才C类
(4) 2021，全国科技系统抗击新冠肺炎疫情先进集体
(5) 2021，福建省高层次人才C类
(6) 2020，全国抗击新冠肺炎疫情先进集体
(7) 2020，Cell出版社中国年度论文奖
(8) 2019，全国教育系统先进集体
2. 学术兼职
(1) The Innovation、Exploration、Health and Metabolism等期刊青年编委
(2) Nature Communications、PLOS Pathogens、Communications Biology、Emerging Microbes & Infections、Vaccines等期刊审稿人
(3) 中国生物物理学会冷冻电镜分会，青年委员
(4) 福建省电镜协会，委员、副秘书长
